Evidence map›Paper›PMID 41040375›Full record

ArticlebioRxiv : the preprint server for biology2025

Pyrazinamide kills

Janïs Laudouze, Tatyana I Rokitskaya, Akira Abolet, Vanessa Point, Alexander M Firsov, Ljudmila S Khailova, Jean-François Cavalier, Stéphane Canaan, Alain R Baulard, Yuri N Antonenko and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Janïs LaudouzeAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Tatyana I RokitskayaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Akira AboletAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Vanessa PointAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Alexander M FirsovBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Ljudmila S KhailovaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Jean-François CavalierAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.ORCID 0000-0003-0864-8314
Stéphane CanaanAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.ORCID 0000-0001-7478-300X
Alain R BaulardUniv. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.ORCID 0000-0002-0150-5241
Yuri N AntonenkoBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-0244-855X
Alexandre GouzyDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0001-6671-7408
Pierre SantucciAix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.ORCID 0000-0002-6291-3425

Funding

Determination of the mode of action of the antibiotic pyrazinamideR21AI168673 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOUZY, ALEXANDRE · 2023 to 2024
$466k
NIAID NIH HHS R21 AI168673
6 · The paper itself

Abstract

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity

Indexed as

acid-base equilibriumacidic environmentsglycerolintrabacterial pH homeostasispantothenateprotonophore

Identifiers

PMID41040375
PMCPMC12486132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.