Evidence map›Paper›PMID 41040365›Full record

ArticlebioRxiv : the preprint server for biology2025

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile.

Shannon L Kordus, Kateryna Nabukhotna, Rubén Cano Rodríguez, Evan Krystofiak, Kevin Childress, Anna J Smith, Natalie Loveridge, William Ball, Grace Moore, M Kay Washington and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shannon L KordusPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1106-4264
Kateryna NabukhotnaPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-0029-5155
Rubén Cano RodríguezPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Evan KrystofiakCell Imaging Shared Resource, Vanderbilt University, Nashville, TN, USA.
Kevin ChildressPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Anna J SmithPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Natalie LoveridgePathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
William BallPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Grace MoorePathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
M Kay WashingtonPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Nicholas MarkhamPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
D Borden LacyPathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-2273-8121

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Antibody and Antigen Discovery for Clostridioides difficile VaccinesU19AI174999 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maribeth Ruth Nicholson · 2023 to 2026
$7.9M
Structural mechanisms of Clostridium difficile pathogenesisR01AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LACY, DANA BORDEN · 2011 to 2020
$3.9M
Structural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2M
Thermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0M
Acquisition of a Focused Ion Beam Scanning Electron Microscope with cryo-stageS10OD028704 · OD · VANDERBILT UNIVERSITY · PI TYSKA, MATTHEW J · 2022 to 2022
$1.6M
Conventional 200 keV Transmission Electron MicroscopeS10OD034315 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JEROME, WALTER G · 2023 to 2023
$597k
Acquisition of a Leica high pressure freezer for the cryo-based electron microscopy techniquesS10MH137068 · NIMH · VANDERBILT UNIVERSITY · PI KRYSTOFIAK, EVAN · 2024 to 2024
$489k
The mechanistic basis for toxin secretion in Clostridioides difficileF32GM139303 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KORDUS, SHANNON L · 2020 to 2022
$206k
Acquisition of a Leica ARTOS 3D UltramicrotomeR24OD037694 · OD · VANDERBILT UNIVERSITY · PI KRYSTOFIAK, EVAN · 2024 to 2024
$139k
BLRD VA I01 BX002943BLRD VA IK2 BX005699NCI NIH HHS P30 CA068485NIAID NIH HHS R01 AI095755NIAID NIH HHS R37 AI095755NIAID NIH HHS U19 AI174999NIDDK NIH HHS P30 DK058404NIGMS NIH HHS F32 GM139303NIH HHS R24 OD037694NIH HHS S10 OD028704NIH HHS S10 OD030292NIH HHS S10 OD034315NIMH NIH HHS S10 MH137068
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41040365
PMCPMC12485765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.