Evidence map›Paper›PMID 41040364›Full record

ArticlebioRxiv : the preprint server for biology2025

A Marfan-Associated FBN1 Nonsense Mutation Mouse Model Reveals Adventitial Inflammation During Aneurysm Progression.

Shichao Wu, Jiawei Zhao, Alejandro Ponce, Lucynda Pham, Daniel Xie, Donghong Ju, Shuping Yin, Francis Hernandez, Sean Jones, Clair Li and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shichao WuDepartment of Internal Medicine.
Jiawei ZhaoDepartment of Internal Medicine.
Alejandro PonceDepartment of Internal Medicine.
Lucynda PhamDepartment of Internal Medicine.
Daniel XieDepartment of Internal Medicine.
Donghong JuDepartment of Internal Medicine.
Shuping YinDepartment of Internal Medicine.
Francis HernandezDepartment of Internal Medicine.
Sean JonesDepartment of Internal Medicine.
Clair LiDepartment of Internal Medicine.
Charles ChungDepartment of Physiology.
Dragana KomnenovDepartment of Physiology.
Noreen F RossiDepartment of Physiology.
Dogukan MizrakDepartment of Cardiac Surgery, University of Michigan, Ann Arbor 48109.
Bo YangDepartment of Cardiac Surgery, University of Michigan, Ann Arbor 48109.
Zhe YangDepartment of Biochemistry Microbiology and Immunology.
Maozhou YangBone and Joint Center, Henry Ford Hospital, Detroit, MI 48202.
Hui LiDepartment of Medicine, University of Massachusetts, Worcester, MA, 01655.
Youming XieAnn Karmanos Cancer Institute.
Kang ChenCenter for Molecular Medicine and Genetics.
Kezhong ZhangCenter for Molecular Medicine and Genetics.
Li LiDepartment of Internal Medicine.ORCID 0000-0001-6598-6358

Funding

The regulatory roles of nuclear SM22 in smooth muscle phenotypic modulationR01HL142956 · NHLBI · WAYNE STATE UNIVERSITY · PI LI, LI · 2018 to 2021
$2.1M
The Role of SM22 in the Pathogenesis of Aortic AneurysmsR01HL119815 · NHLBI · WAYNE STATE UNIVERSITY · PI LI, LI · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL119815NHLBI NIH HHS R01 HL142956
6 · The paper itself

Abstract

Marfan syndrome (MFS) is a genetic disorder caused by mutations in

Identifiers

PMID41040364
PMCPMC12485906

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.