ArticlebioRxiv : the preprint server for biology2025
A Daily Cycle of White Collar Complex Dephosphorylation Sustains Circadian Rhythmicity in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
As a photoreceptor, the transcription factor complex WCC acutely activates ∼5% of the genome in response to blue light, while as the circadian positive element in the dark WCC influences expression of about 40% of the transcriptome. Among WCC-regulated genes is Significance: At the core of circadian clocks of fungi and animals, a protein heterodimer drives expression of gene(s) whose products inactivate the heterodimer via phosphorylation. To sustain the cycle through multiple days, the activity of the heterodimer must be restored, but the means through which this happens have been unclear. In the clock model
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