ArticlebioRxiv : the preprint server for biology2025
Regulation of Decision Threshold by the Locus Coeruleus.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A fundamental challenge for decision-making under uncertainty lies in regulating the balance between speed and accuracy. Humans and animals solve this problem by adjusting their decision thresholds - the criterion that determines how much information is required before committing to a choice. While brain regions associated with this process have been identified, the neural circuits able to Highlights: LC-NE activation increases reaction time and accuracy of perceptual decisionsBehavioral effects are consistent with an elevation of decision thresholdsHeightened decision thresholds are replicated by selective activation of α2 ARsActivation of LC-NE and α2 ARs differently alter task engagement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.