In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Ashley J CuttittaDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2400-4087 Sophia R MeyerDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7301-8370 Tristan FrumDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3452-8762 Bhargavasai GunuguntlaDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Angeline WuDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sha HuangDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jack MorganDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Michael K DameDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3760-1654 Jonathan Z SextonDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9244-5888 Jason R SpenceDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7869-3992 Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MConsortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyRC2DK140862 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI SARAH E BLUTT, DARIO BOFFELLI · 2024 to 2026
$6.0MNiche support of human intestinal stem cellsU01DK103141 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2014 to 2023
$3.9MHuman iPSC intestine mimetics with integrated mesenchymal, endothelial and enteric nervous tissueR01DK137806 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2024 to 2026
$1.5MLaser-based high content imaging microscopeS10OD034245 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEXTON, JONATHAN ZACHARY · 2024 to 2024
$1.4MNCI NIH HHS P30 CA046592NIAMS NIH HHS P30 AR069620NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK137806NIDDK NIH HHS RC2 DK140862NIDDK NIH HHS U01 DK103141NIH HHS S10 OD034245
6 · The paper itselfAbstract
Background & Aims: Human Methods: Using 3-dimensional (3D) primary human colonoids, we seeded dissociated epithelium onto 96-well transwell membranes and added different media that was growth factor specific to apical or basolateral transwell chambers. Barrier integrity was assessed using a variety of stimuli and TEER was continuously monitored in real time for up to 2 weeks, followed by quantitative single-cell image analysis using high-content imaging and deep-learning-based cell segmentation. Results: Epithelium cultured up to 30 days sustained a time-dependent differentiation, leading to the establishment of a monolayer with proliferative stem/progenitor and differentiated cell types. While monitoring continuous TEER across multiple donor organoids, barrier challenge assays recorded donor-specific responses to IFN-γ, TNF-α, Conclusions: We demonstrate a high-throughput
Indexed as
2Dhigh-content imagingorganoidTEER
Identifiers
PMID41040326
PMCPMC12485924
What OpenQuestion holds
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