Evidence map›Paper›PMID 41040321›Full record

ArticlebioRxiv : the preprint server for biology2025

Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing.

Jin Cho, Clark L Hendrickson, Nathan Mar, Ira L Blitz, Margaret Fish, Wenqi Wang, Ken W Y Cho

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin ChoDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Clark L HendricksonDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Nathan MarDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Ira L BlitzDevelopmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-0173-3287
Margaret FishDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Wenqi WangDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Ken W Y ChoDevelopmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0001-7282-1770

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Zygotic Genome Activation by Maternal Transcription Factors and Epigenetic ModifiersR35GM139617 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ken W.Y. Cho · 2021 to 2026
$2.6M
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
Spatiotemporal mapping of enhancer activity in developing frog embryosR21HD109696 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHO, KEN W.Y. · 2022 to 2023
$417k
NCI NIH HHS P30 CA062203NIAMS NIH HHS P30 AR075047NICHD NIH HHS R21 HD109696NIGMS NIH HHS R35 GM139617NIH HHS S10 OD010794NIH HHS S10 OD021718
6 · The paper itself

Abstract

Polycomb Repressive Complex 2 (PRC2) establishes H3K27me3 marks to shape spatiotemporal gene expression during embryogenesis. While its dysregulation is linked to developmental disorders, cancer, and aging, the mechanisms guiding PRC2 to specific genomic loci remain a subject of ongoing debate. A prevailing model proposes that PRC2 recruitment occurs via its intrinsic affinity for chromatin rather than through sequence-specific transcription factors. Here, we provide evidence that the maternally deposited pioneer transcription factor Foxh1 plays a critical role in directing PRC2 to specific genomic loci during zygotic genome activation in

Indexed as

CRISPR/Cas9ectodermendodermepigeneticsmaternal transcription factorsrepressive histone markXenopus tropicaliszygotic genome activation

Identifiers

PMID41040321
PMCPMC12485744

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.