Evidence map›Paper›PMID 41040316›Full record

ArticlebioRxiv : the preprint server for biology2025

Paying upfront: successful initial infections protect against severe future infections.

K M Talbott, A E Fleming-Davies, A A Perez-Umphrey, A E Henschen, J Garrett-Larsen, F E Tillman, J N Weil, A G Arneson, S J Geary, E R Tulman and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

K M TalbottDepartment of Biological Sciences, University of Memphis, Memphis, TN 38152.ORCID 0000-0003-1974-1899
A E Fleming-DaviesDepartment of Biology, University of San Diego, San Diego, CA 92110.ORCID 0000-0003-1609-7014
A A Perez-UmphreyDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 Department of.ORCID 0000-0001-8876-1872
A E HenschenDepartment of Biological Sciences, University of Memphis, Memphis, TN 38152.ORCID 0000-0002-6288-5575
J Garrett-LarsenDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 Department of.
F E TillmanDepartment of Biological Sciences, University of Memphis, Memphis, TN 38152.ORCID 0000-0002-9439-1895
J N WeilDepartment of Biological Sciences, University of Memphis, Memphis, TN 38152.ORCID 0009-0009-3121-3352
A G ArnesonDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 Department of.ORCID 0000-0002-1027-5206
S J GearyDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269.ORCID 0000-0003-3653-6360
E R TulmanDepartment of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269.ORCID 0000-0002-2682-5145
L M ChildsDepartment of Mathematics, Virginia Tech, Blacksburg, VA 24061.ORCID 0000-0003-3904-3895
K E LangwigDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 Department of.ORCID 0000-0001-8318-1238
D M HawleyDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061 Department of.ORCID 0000-0001-9573-2914
J S AdelmanDepartment of Biological Sciences, University of Memphis, Memphis, TN 38152.ORCID 0000-0002-5577-8798

Funding

Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposureR01GM144972 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HAWLEY, DANA M · 2021 to 2024
$2.0M
NIGMS NIH HHS R01 GM144972
6 · The paper itself

Abstract

Understanding the consistency with which individual hosts respond to repeated pathogen exposures is crucial for accurately modeling pathogen transmission and eco-evolutionary dynamics. When hosts face repeated pathogen exposures, immune memory is expected to reduce the probability and/or severity of subsequent infections, yet it remains unclear whether individuals remain consistent in their level of response relative to others. We investigated this question in house finches (

Identifiers

PMID41040316
PMCPMC12485878

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.