Evidence map›Paper›PMID 41040306›Full record

ArticlebioRxiv : the preprint server for biology2025

Translation Inhibition by Rocaglamide A Enhances Susceptibility of Yeasts to Caspofungin.

Qian He, Peter J Schuessler, Aravind Srinivasan, Jessie Caprino, Joseph Barbi, Sarah E Walker

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qian HeDepartment of Biological Sciences, SUNY at Buffalo, Buffalo, New York, 14260, USA.
Peter J SchuesslerDepartment of Biological Sciences, SUNY at Buffalo, Buffalo, New York, 14260, USA.
Aravind SrinivasanDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, 14263, USA.
Jessie CaprinoDepartment of Biological Sciences, SUNY at Buffalo, Buffalo, New York, 14260, USA.
Joseph BarbiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, 14263, USA.
Sarah E WalkerDepartment of Biological Sciences, SUNY at Buffalo, Buffalo, New York, 14260, USA.ORCID 0000-0002-9983-2485

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Molecular mechanisms of eukaryotic translational controlR01GM139977 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Sarah Elizabeth Walker · 2022 to 2026
$1.8M
Translational control by the eIF4 factorsR00GM119173 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WALKER, SARAH ELIZABETH · 2015 to 2017
$746k
NCI NIH HHS P30 CA013696NIGMS NIH HHS R00 GM119173NIGMS NIH HHS R01 GM139977
6 · The paper itself

Abstract

Fks1 catalyzes the synthesis of β-1,3-glucans, a major structural component of the fungal cell wall, and is the primary target of the antifungal drug caspofungin. Mutations in Fks1 confer caspofungin resistance by disrupting its interaction with the drug, thereby reducing inhibition of Fks1 enzymatic activity. Previous studies demonstrated that translation of the

Identifiers

PMID41040306
PMCPMC12485697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.