Evidence map›Paper›PMID 41040303›Full record

ArticlebioRxiv : the preprint server for biology2025

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia.

So M V Kamalakannan, Alie G Male, Musa Yilan Li, Annalisa Lella, Jaylen Lee, Yann Quidé, Melissa J Green, Murray J Cairns, Vaughan J Carr, Stanley Catts and 51 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors.

So M V KamalakannanClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, 92697-3950, USA.
Alie G MaleClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, 92697-3950, USA.
Musa Yilan LiNationwide Childrens Hospital, Columbus, Ohio.
Annalisa LellaClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, 92697-3950, USA.
Jaylen LeeBiostatistics, Epidemiology, & Research Design Unit, Institute for Clinical and Translational Sciences, University of California, Irvine, CA, 92697, USA.
Yann QuidéNeurorecovery Research Hub, School of Psychology, The University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-8569-7139
Melissa J GreenDiscipline of Psychiatry and Mental Health, The University of New South Wales, Sydney, NSW, Australia.
Murray J CairnsSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.ORCID 0000-0003-2490-2538
Vaughan J CarrDiscipline of Psychiatry and Mental Health, The University of New South Wales, Sydney, NSW, Australia.
Stanley CattsQueensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Frans A HenskensSchool of Medicine and Public Health, University of Newcastle, NSW, Australia.
Assen JablenskyThe University of Western Australia, Perth, Australia.
Carmel LoughlandSchool of Medicine and Public Health, University of Newcastle.
Patricia MichieSchool of Biomedical Science and Pharmacy, University of Newcastle, NSW, Australia.
Bryan MowryQueensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.
Christos PantelisDepartment of Psychiatry, The University of Melbourne, Carlton South, VIC, Australia.ORCID 0000-0002-9565-0238
Ulrich ShallSchool of Biomedical Science and Pharmacy, University of Newcastle, NSW, Australia.
Rodney J ScottSchool of Biomedical Science and Pharmacy, University of Newcastle, NSW, Australia.
Ayse BelgerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Juan BustilloUniversity of New Mexico, Department of Psychiatry.
Kelvin LimDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN USA.
Judith M FordUniversity of California San Francisco.
Daniel H MathalonUniversity of California San Francisco.
Adrian PredaUniversity of California Irvine, Department of Psychiatry and Human Behavior.
Bryon MuellerDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Steven G PotkinUniversity of California Irvine, Department of Psychiatry and Human Behavior.
Theodore D SatterhwaiteDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine.ORCID 0000-0001-7072-9399
Ruben C GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine.
Nerisa BanajLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.
Daniela VecchioLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.
Fabrizio PirasLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.
Federica PirasLaboratory of Neuropsychiatry, Department of Clinical Neuroscience and Neurorehabilitation, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID 0000-0002-9546-7038
Stefan EhrlichDivision of Psychological & Social Medicine and Developmental Neurosciences, Technischen Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus Dresden, Germany.
Fabio BernardoniDivision of Psychological & Social Medicine and Developmental Neurosciences, Technischen Universität Dresden, Faculty of Medicine, University Hospital C.G. Carus Dresden, Germany.
Stefan BorgwardtDepartment of Psychiatry and Psychotherapy, University of Lübeck, Germany.
Derin CobiaDepartment of Psychology, Brigham Young University.ORCID 0000-0003-2339-958X
Kate AlpertWashington University School of Medicine.
Lei WangThe Ohio State University Wexner Medical Center.
Ingrid AgartzCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
Erik G JönssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
Stefan KaiserDivision of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, 1226 Thônex, Switzerland.
Edith Pomarol-ClotetFIDMAG Sisters Hospitallers Research Foundation.
Raymond SalvadorFIDMAG Sisters Hospitallers Research Foundation.
Carlos López-JaramilloResearch Group in Psychiatry (GIPSI), Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellin, Colombia.
Ana M Diaz-ZuluagaResearch Group in Psychiatry (GIPSI), Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellin, Colombia.
Julian Pineda-ZapataResearch Group in Psychiatry (GIPSI), Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medellin, Colombia.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Germany.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Germany.
Axel KrugDepartment of Psychiatry and Psychotherapy, University of Marburg, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Jan-Bernard Marsmancenter for Clinical Neuroscience and Cognition, University Medical Center Groningen, The Netherlands.
André AlemanDepartment of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Anthony O AhmedDepartment of Psychiatry, Weill Cornell Medicine, New York, USA.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA.
Paul A ThompsonImaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-4720-8867
Matthias KrischnerDivision of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, 1226 Thônex, Switzerland.ORCID 0000-0002-9486-1439
Vince D CalhounTReNDS Center (Georgia State, Georgia Tech, Emory), Atlanta, GA 30303.ORCID 0000-0001-9058-0747
Jessica A TurnerDepartment of Psychiatry & Behavioral Health, the Ohio State University Wexner Medical Center, Columbus Ohio 43210.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine Hall, room 109, Irvine, CA, 92697-3950, USA.ORCID 0000-0002-2465-2797

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
FUNCTION BIRNU24RR021992 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTKIN, STEVEN G · 2006 to 2010
$25.0M
MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HAMALAINEN, MATTI · 1999 to 2011
$16.4M
BIO-INFORMATICS RESEARCH NETWORK COORDINATING CENTER (BIRN-CC)U24RR025736 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL · 2009 to 2011
$15.0M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
ENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0M
Evolution of Psychosis in Youth: Multimodal Risk and Resilience MarkersR01MH119219 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E, GUR, RUBEN C. · 2019 to 2023
$3.8M
SchizConnect: Large-Scale Schizophrenia Neuroimaging Data Mediation & FederationU01MH097435 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AMBITE, JOSE LUIS, POTKIN, STEVEN G · 2013 to 2016
$2.0M
Genetic markers of white matter integrity in schizophrenia: Relationship to cliniRC1MH089257 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2009 to 2010
$985k
CSRD VA IK6 CX002519NCRR NIH HHS P41 RR014075NCRR NIH HHS U24 RR021382NCRR NIH HHS U24 RR021992NCRR NIH HHS U24 RR025736NCRR NIH HHS UL1 RR025758NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIMH NIH HHS P30 MH097488NIMH NIH HHS R01 MH084803NIMH NIH HHS R01 MH119219NIMH NIH HHS R01 MH121246NIMH NIH HHS R21 MH097196NIMH NIH HHS RC1 MH089257NIMH NIH HHS U01 MH097435
6 · The paper itself

Abstract

Background: Schizophrenia is characterized by widespread structural brain abnormalities, but associations between structural abnormalities and negative symptom severity are not well understood. Negative symptoms have been conceptualized in a hierarchical structure of two second-order dimensions-motivation and pleasure (MAP) and expression (EXP)-and five first-order domains: anhedonia, avolition, and asociality (MAP), and blunted affect and alogia (EXP). A better understanding of the neural circuitry underlying negative symptom dimensions and domains is important given their reported association with poor functional outcome and lack of available treatments. Study Design: The meta-analysis included 1,591 individuals with schizophrenia across 16 samples with structural imaging and Scale for Assessment of Negative Symptoms data. The study generated correlations of cortical thickness and subcortical volumes with the negative symptom dimensions and domains. Study results: Negative symptoms showed mainly negative associations with cortical thickness and subcortical volumes. The effect sizes were small but there was a pattern of associations in predominantly frontal lobe cortical thickness and limbic subcortical volumes. The regional correlation patterns of cortical thickness and subcortical volumes with symptom domains support the conceptualized hierarchical structure of negative symptoms: correlations of MAP domains were stronger with the MAP than EXP dimension, and vice versa. Exploratory analyses with receptor densities further supported the hierarchy. Conclusion: Our findings reveal small but consistent associations between negative symptom dimensions and predominantly prefrontal region cortical thickness, and limbic region volumes. These findings advance our understanding of the network of anatomical regions that may contribute to the severity of negative symptoms in schizophrenia.

Indexed as

EXPexperientialexpressivefactornegative symptomsreceptorschizophreniathicknessvolume

Identifiers

PMID41040303
PMCPMC12485849

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