Evidence map›Paper›PMID 41040289›Full record

ArticlebioRxiv : the preprint server for biology2025

Microbial lipid shifts in a multi-stage simulated gut.

Ifrat Tamanna, Katja Salonen, Helena Mannochio-Russo, Matilda Kråkström, Paulo Wender P Gomes, Vincent Charron Lamoureux, Ipsita Mohanty, Sofia D Forssten, Arthur C Ouwehand, Tuulia Hyötyläinen and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ifrat TamannaResearch Center for Infections and Immunity, Institute of Biomedicine, University of Turku and Turku University Hospital, Turku, Finland.
Katja SalonenTurku Bioscience, University of Turku and Åbo Akademi University, Turku 20520 Finland.
Helena Mannochio-RussoCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Matilda KråkströmTurku Bioscience, University of Turku and Åbo Akademi University, Turku 20520 Finland.
Paulo Wender P GomesFaculty of Chemistry, Federal University of Pará, Belém, PA, Brazil.
Vincent Charron LamoureuxCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Ipsita MohantyCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Sofia D ForsstenIFF Health Sciences, 02460 Kantvik Finland.
Arthur C OuwehandIFF Health Sciences, 02460 Kantvik Finland.
Tuulia HyötyläinenDepartment of Chemistry, Örebro University, 70281 Örebro Sweden.
Alex M DickensTurku Bioscience, University of Turku and Åbo Akademi University, Turku 20520 Finland.
Pieter C DorresteinCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Matej OrešičTurku Bioscience, University of Turku and Åbo Akademi University, Turku 20520 Finland.
Santosh LamichhaneResearch Center for Infections and Immunity, Institute of Biomedicine, University of Turku and Turku University Hospital, Turku, Finland.

Funding

Collaborative Microbial Metabolite CenterU24DK133658 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2022 to 2026
$2.9M
Reverse Metabolomics for the Discovery of Disease Associated Microbial MoleculesR01DK136117 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2023 to 2026
$2.9M
NIDDK NIH HHS R01 DK136117NIDDK NIH HHS U24 DK133658
6 · The paper itself

Abstract

Food residues that bypass human digestion are further digested by gut microbes, leading to the production of diverse metabolites, including lipids. To investigate how lipids are affected during this transition, we used a colon simulator with four distinct vessels that mimics the proximal to distal part of the human colon. We observed dynamic shifts in a diverse array of microbially derived lipid molecules in the simulated intestinal chyme, including bile acids and

Identifiers

PMID41040289
PMCPMC12485695

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.