Evidence map›Paper›PMID 41040276›Full record

ArticlebioRxiv : the preprint server for biology2025

Central carbon metabolism switching in lytic versus temperate coral reef viral communities.

Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Rob Edwards, Natalie A Falta, Emma George, Eleanor Gorham, Juris Grasis and 22 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Jacob KelmanDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Meena KhanDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Chibundu UmunnaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Russell BrainardR Ocean LLC, Kāne'ohe, Hawaii 96744, USA.
Grace DonohueDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Rob EdwardsFlinders Accelerator for Microbiome Exploration, Flinders University, Bedford Park, South Australia 5042, Australia.ORCID 0000-0001-8383-8949
Natalie A FaltaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Emma GeorgeBiology Department, San Diego State University, San Diego, California 92182, USA.
Eleanor GorhamDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Juris GrasisSchool of Natural Sciences, University of California, Merced, Merced, California 95343, USA.
Kevin GreenBiology Department, San Diego State University, San Diego, California 92182, USA.
Andreas HaasBiology Department, San Diego State University, San Diego, California 92182, USA.
Kimberly HalseyDepartment of Microbiology, Oregon State University, Corvallis, Oregon 97331, USA.
Eric HesterBiology Department, San Diego State University, San Diego, California 92182, USA.
Summer JacobDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Aydin Loid KaratasDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Yan Wei LimBiology Department, San Diego State University, San Diego, California 92182, USA.
Mark LittleBiology Department, San Diego State University, San Diego, California 92182, USA.
Stuart SandinMarine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, USA.
Jessie SegnitzDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Maya SerotaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Natalia ShahwanDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Giselle SimmonsDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Jennifer E SmithMarine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, USA.
Isha TripathiDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Linda Wegley KellyMarine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, USA.
Lauren WoodwardDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Nickie YangDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.
Charles YoungPacific Islands Ocean Observing System, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
Brian ZgliczynskiMarine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, USA.
Forest RohwerBiology Department, San Diego State University, San Diego, California 92182, USA.
Ben KnowlesDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA.

Funding

Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)RC2DK116713 · NIDDK · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2019 to 2023
$8.9M
NIDDK NIH HHS RC2 DK116713
6 · The paper itself

Abstract

Coral reefs are declining globally due in part to bacterial overgrowth, a process known as microbialization. However, the role of bacteriophages that may inhibit microbialization by infecting and killing these bacteria remains poorly understood, especially their metabolic impacts on bacterial proliferation. To address this, we analyzed central carbon metabolism gene frequencies in viral communities from healthy (lytic-dominated) and degraded (temperate-dominated) Central Pacific coral reefs. We found that viral metabolism shifted broadly from being dominated by metabolism that builds up pools of central intermediates on degraded reefs dominated by temperate viral infection ('anaplerotic' reactions) to metabolism that consumes these pools to prioritize production of metabolic precursors for virion construction on healthy reefs dominated by lytic infection ('cataplerotic' reactions). This switch was shown by the over-representation of Entner-Doudoroff (ED) glycolysis genes on degraded, temperate-dominated reefs and of pentose phosphate pathway (PPP) and reductive tricarboxylic acid cycle (TCA) genes on healthy, lytic-dominated reefs. As a result of this metabolic dichotomy, our qualitative compartment modeling revealed two distinct ecosystem states: (i) healthy reefs, where lytic viral metabolism enhances viral production and suppresses bacterial overgrowth, and (ii) degraded reefs, where temperate viral metabolism accelerates bacterial proliferation. Because viral switching between lytic and temperate lifestyles is a known function of host physiological state, these findings position viral metabolism as both a driver of reef decline and a conservation lever, with metabolically mediated 're-viralization' offering a novel strategy to restore reef resilience.

Identifiers

PMID41040276
PMCPMC12485937

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.