Evidence map›Paper›PMID 41040234›Full record

ArticlebioRxiv : the preprint server for biology2025

GBP1 recruitment to actin-rich pedestals induced by extracellular Gram negative bacteria promotes pyroptosis.

Daniel J Bennison, Ishaan Chaudhary, Dharitri Chaudhuri, Justin Chun Ngai Wong, Priyanka Biswas, Qiyun Zhong, Wouter W Kallemeijn, Marianne Guenot, Arthur M Talman, Eva-Maria Frickel and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Daniel J BennisonDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Ishaan ChaudharyDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Dharitri ChaudhuriDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Justin Chun Ngai WongDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Priyanka BiswasDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Qiyun ZhongDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Wouter W KallemeijnThe Francis Crick Institute, London, United Kingdom.
Marianne GuenotDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Arthur M TalmanMIVEGEC, University of Montpellier, IRD, CNRS, Montpellier, France.
Eva-Maria FrickelDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Edward W TateThe Francis Crick Institute, London, United Kingdom.ORCID 0000-0003-2213-5814
Sandhya S VisweswariahDepartment of Developmental Biology & Genetics, Indian Institute of Science, Bengaluru, India.
Gad FrankelDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Avinash R ShenoyDepartment of Infectious Disease, Imperial College London, London, United Kingdom.ORCID 0000-0001-6228-9303

Funding

Mechanisms underlying diarrhea and gut inflammation mediated by Enterotoxigenic and Enteropathogenic E. coliR01AI169618 · NIAID · INDIAN INSTITUTE OF SCIENCE · PI Sandhya Visweswariah · 2023 to 2026
$482k
NIAID NIH HHS R01 AI169618Wellcome Trust FC001002Wellcome Trust FC001057
6 · The paper itself

Abstract

The IFNγ-induced GTPase guanylate binding protein 1 (GBP1) binds to lipopolysaccharide (LPS) on cytosolic Gram-negative bacteria and promotes pyroptosis via the recruitment and activation of caspase-4 on the bacterial outer membrane. Enteropathogenic and enterohaemorrhagic

Identifiers

PMID41040234
PMCPMC12485797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.