Evidence map›Paper›PMID 41040230›Full record

ArticlebioRxiv : the preprint server for biology2025

Engineering Spatial Control of Bacterial Organelles.

Y Hoang, Pankaj V Jadhav, Daniel S Trettel, Rachel E Dow, Seokmu Kwon, Kate Matej, Jordan A Byrne, Christopher A Azaldegui, Tobias W Giessen, Hualiang Pi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Y HoangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan; Ann Arbor, MI 48109, USA.
Pankaj V JadhavLife Sciences Institute, University of Michigan; Ann Arbor, MI 48108, USA.
Daniel S TrettelLos Alamos National Laboratory, Bioscience Division, Microbial and Biome Sciences Group; Los Alamos, NM 87544, USA.
Rachel E DowDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan; Ann Arbor, MI 48109, USA.
Seokmu KwonDepartment of Biological Chemistry, University of Michigan; Ann Arbor, MI 48109, USA.
Kate MatejDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine; New Haven, CT 06510, USA.
Jordan A ByrneDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan; Ann Arbor, MI 48109, USA.
Christopher A AzaldeguiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan; Ann Arbor, MI 48109, USA.
Tobias W GiessenDepartment of Biological Chemistry, University of Michigan; Ann Arbor, MI 48109, USA.ORCID 0000-0001-6328-2031
Hualiang PiDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine; New Haven, CT 06510, USA.
Shyamal MosalagantiLife Sciences Institute, University of Michigan; Ann Arbor, MI 48108, USA.
Anthony G VecchiarelliDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan; Ann Arbor, MI 48109, USA.ORCID 0000-0002-6198-3245

Funding

Protein Organelles In Human-Associated BacteriaR35GM133325 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Tobias Wolfgang Giessen · 2019 to 2026
$3.8M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
In-situ architecture of membrane contact sites mediating organelle fissionDP2GM150019 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOSALAGANTI, SHYAMAL · 2022 to 2025
$2.3M
Coordinated Spatial Organization in BacteriaR35GM152128 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Anthony G Vecchiarelli · 2024 to 2026
$1.1M
Compute Cluster for in vitro and in situ Analysis of Molecular MachinesS10OD030275 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OHI, MELANIE DIANE · 2021 to 2021
$600k
Quality control and spatial regulation of bacterial condensatesK99GM157383 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Y Hoang · 2025 to 2026
$127k
NIGMS NIH HHS DP2 GM150019NIGMS NIH HHS K99 GM157383NIGMS NIH HHS R35 GM133325NIGMS NIH HHS R35 GM152128NIGMS NIH HHS T32 GM145304NIH HHS S10 OD030275
6 · The paper itself

Abstract

Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacterial organelles are organized in the cell, and whether their spatial control can be engineered. Here, we show that a two-protein system (McdAB) that positions carboxysomes-CO

Identifiers

PMID41040230
PMCPMC12485843

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.