Evidence map›Paper›PMID 41040221›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons.

Özgün Uyan, Snehal Sambare, Marlies E Oomen, Nicholas Wightman, Allana Schooley, Joseph R Klim, Houda Belaghzal, Özkan Aydemir, Betul Akgol-Oksuz, Zeynep Sena Agim Uslu and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Özgün UyanDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Snehal SambareDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.
Marlies E OomenDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.
Nicholas WightmanDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Allana SchooleyDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.
Joseph R KlimDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Houda BelaghzalDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.
Özkan AydemirProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Betul Akgol-OksuzDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.
Zeynep Sena Agim UsluDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Kevin EgganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Robert H BrownDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Job DekkerDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605-0103, USA.ORCID 0000-0001-5631-0698

Funding

Expanding the chemical diversity of therapeutic oligonucleotides to treat neurodegenerative disordersR01NS104022 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANASTASIA KHVOROVA · 2017 to 2026
$6.0M
Next-generation antisense therapeutics for ALS and frontotemporal dementiaR01NS111990 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Robert H Brown, Jonathan K Watts · 2019 to 2026
$5.2M
Development of Mutant Specific Antisense Oligonucleotides for TARDBP and KIF5A as a Therapeutic for ALS/FTDR21NS139270 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LANDERS, JOHN E · 2024 to 2024
$461k
NINDS NIH HHS R01 NS104022NINDS NIH HHS R01 NS111990NINDS NIH HHS R21 NS139270
6 · The paper itself

Abstract

We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expansions in the

Identifiers

PMID41040221
PMCPMC12485917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.