Evidence map›Paper›PMID 41040214›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues.

K M Mellor, U Varma, P Koutsifeli, C L Curl, J V Janssens, L J Daniels, G B Bernasochi, A J A Raaijmakers, M Annandale, X Li and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

K M MellorDepartment of Physiology, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-8443-9365
U VarmaDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
P KoutsifeliDepartment of Physiology, University of Auckland, Auckland, New Zealand.
C L CurlDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
J V JanssensDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
L J DanielsDepartment of Physiology, University of Auckland, Auckland, New Zealand.
G B BernasochiDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
A J A RaaijmakersDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
M AnnandaleDepartment of Physiology, University of Auckland, Auckland, New Zealand.
X LiDepartment of Physiology, University of Auckland, Auckland, New Zealand.
S L JamesDepartment of Physiology, University of Auckland, Auckland, New Zealand.
D J TaylorCedars-Sinai Medical Center, Los Angeles, California, USA.
K RaedscheldersCedars-Sinai Medical Center, Los Angeles, California, USA.
K L WeeksDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
R J MillsMurdoch Children's Research Institute, Melbourne, Victoria, Australia.
R G PartonCentre for Microscopy and Microanalysis and Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
X HuInstitute of Molecular Medicine, Peking University, Beijing, China.
J R BellDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
Terence J O'BrienDepartment of Medicine, University of Melbourne & Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Rajesh KatareDepartment of Physiology, HeartOtago, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-5419-7935
E R PorrelloDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.
J E HudsonSchool of Biomedical Sciences, University of Queensland & QIMR Berghofer, Brisbane, Queensland, Australia.
R-P XiaoInstitute of Molecular Medicine, Peking University, Beijing, China.
J E Van EykCedars-Sinai Medical Center, Los Angeles, California, USA.
R A GottliebCedars-Sinai Medical Center, Los Angeles, California, USA.
L M D DelbridgeDepartment of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia.

Funding

Exosome Therapeutics to Dissect HFpEF MechanismsR01HL155346 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI MARBAN, EDUARDO, VAN EYK, JENNIFER E · 2021 to 2024
$3.3M
Regulation of the Dynamic Proteome after Ischemic InjuryR01HL144509 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOTTLIEB, ROBERTA A., VAN EYK, JENNIFER E · 2019 to 2022
$2.9M
NHLBI NIH HHS R01 HL144509NHLBI NIH HHS R01 HL155346
6 · The paper itself

Abstract

Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted therapies. Recently, disrupted glycogen-autophagy (glycophagy) and glycogen accumulation have been identified in the diabetic heart. Glycophagy involves glycogen receptor binding and linking with an ATG8 protein to locate and degrade glycogen within an intracellular phago-lysosome. Here we show that glycogen receptor protein STBD1 (starch-binding-domain-protein-1) is mobilized early in the cardiac glycogen response to metabolic challenge

Identifiers

PMID41040214
PMCPMC12485856

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.