Evidence map›Paper›PMID 41040194›Full record

ArticlebioRxiv : the preprint server for biology2025

Computer models predict differential dendritic vulnerability with ischemia and spreading depression.

Adam J H Newton, William W Lytton, Marcello DiStasio, Robert A McDougal

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Adam J H NewtonDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, United States.ORCID 0000-0002-4726-2644
William W LyttonDepartment of Physiology and Pharmacology, SUNY Downstate Health Sciences University, Brooklyn, NY, United States.ORCID 0000-0002-3727-2849
Marcello DiStasioDepartments of Pathology and of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, United States.ORCID 0000-0001-6588-0713
Robert A McDougalDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, United States.ORCID 0000-0001-6394-3127

Funding

Extension of NEURON simulator for simulation of reaction-diffusion in neuronsR01MH086638 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI LYTTON, WILLIAM W, MCDOUGAL, ROBERT A. · 2010 to 2025
$6.0M
NIMH NIH HHS R01 MH086638
6 · The paper itself

Abstract

Ischemia, whether abrupt or chronic, limits ATP production and disrupts ATP-dependent homeostatic mechanisms, leading to alterations in both intracellular and extracellular ion concentrations. Inadequate neuronal ATP triggers K

Indexed as

dendritic beadingexcitotoxicityion homeostasisischemiareaction-diffusionsimulationspreading depolarization

Identifiers

PMID41040194
PMCPMC12485914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.