Evidence map›Paper›PMID 41040159›Full record

ArticlebioRxiv : the preprint server for biology2025

In Vitro Evidence to Support Amphotericin B and Flucytosine Combination Therapy for Talaromycosis.

Heera Natesan Sambath, Shawin Vitsupakorn, Kaushik Sreerama Reddy, Lottie Brown, Thu Nguyen Thi Mai, Matthew Burke, Jialin Liu, Emily Evans, Charles Giamberardino, John Perfect and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Heera Natesan SambathDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0007-8729-6121
Shawin VitsupakornDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.
Kaushik Sreerama ReddyDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6745-4109
Lottie BrownInstitute of Infection and Immunity, City St George's University of London, School of Health & Medical Sciences, London, UK.ORCID 0000-0001-9896-8682
Thu Nguyen Thi MaiDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0004-4003-3269
Matthew BurkeDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0001-4062-4024
Jialin LiuDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0009-0003-3645-0089
Emily EvansEmory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0009-5933-2839
Charles GiamberardinoDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7813-5616
John PerfectDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.
Hoa Ngo ThiTropical Medicine Research Center for Talaromycosis, Biomedical Research Center, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Thuy LeDivision of Infectious Diseases and International Health, Duke University School of Medicine, Durham, North Carolina, USA.

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaR01AI143409 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2019 to 2024
$2.8M
Tropical Medicine Research Center for Talaromycosis in VietnamU01AI169358 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2022 to 2026
$2.5M
Implications of mycoviral infection in Talaromyces marneffei: an analysis of human patient samples, RNAi, and hypermutationR21AI159397 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH, LE, THUY · 2021 to 2022
$443k
Mapping of the IgM and IgG antibody responses to Talaromyces marneffei infection in mice and humans - Deciphering acute from reactivated or latent infectionsR21AI162367 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2021 to 2022
$434k
NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI143409NIAID NIH HHS R21 AI159397NIAID NIH HHS R21 AI162367NIAID NIH HHS U01 AI169358
6 · The paper itself

Abstract

Background: Methods: The in vitro antifungal activity of AmB and 5FC alone and in combination against 60 Results: The MIC Conclusions: Our study demonstrated in vitro evidence of synergistic activity between AmB and 5FC against Lay Summary: This study demonstrated in vitro synergy between amphotericin B and flucytosine against

Indexed as

amphotericin Bcombination therapyflucytosineTalaromyces marneffeiTalaromycosis

Identifiers

PMID41040159
PMCPMC12485967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.