Evidence map›Paper›PMID 41040152›Full record

ArticlebioRxiv : the preprint server for biology2025

Lactate promotes longevity through redox-driven lipid remodeling in

Arnaud Tauffenberger, Payton J Netherland, Hubert Fiumelli, Joshua D Meisel, Frank C Schroeder, Pierre Magistretti

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arnaud TauffenbergerKing Abdullah University of Science and Technology, 4700 KAUST, Thuwal, KSA.ORCID 0000-0003-0207-9659
Payton J NetherlandBoyce Thompson Institute, 533 Tower Road, Ithaca, NY, USA.
Hubert FiumelliKing Abdullah University of Science and Technology, 4700 KAUST, Thuwal, KSA.ORCID 0000-0001-5136-3045
Joshua D MeiselDepartment of Biology, Brandeis University, Waltham, MA, USA.ORCID 0000-0002-6944-5177
Frank C SchroederBoyce Thompson Institute, 533 Tower Road, Ithaca, NY, USA.ORCID 0000-0002-4420-0237
Pierre MagistrettiKing Abdullah University of Science and Technology, 4700 KAUST, Thuwal, KSA.ORCID 0000-0002-6678-320X

Funding

Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
Identification of genetic and environmental suppressors of mitochondrial dysfunctionR00GM140217 · NIGMS · BRANDEIS UNIVERSITY · PI Joshua Daniel Meisel · 2025 to 2026
$498k
NIGMS NIH HHS R00 GM140217NIGMS NIH HHS R35 GM131877
6 · The paper itself

Abstract

Lactate has emerged as a key metabolite involved in multiple physiological processes, including memory formation, immune response regulation, and muscle biogenesis. However, its role in aging and cellular protection remains unclear. Here, we show that lactate promotes longevity in

Identifiers

PMID41040152
PMCPMC12485788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.