Evidence map›Paper›PMID 41040150›Full record

ArticlebioRxiv : the preprint server for biology2025

Cross-species phenotypic profiling uncovers functional determinants of bacterial cold shock adaptation.

Hao Fan, Andrew Briercheck, Vivek K Mutalik, Mengwen Xiong, Yan Zhang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao FanDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Andrew BriercheckDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Vivek K MutalikEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Mengwen XiongDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Yan ZhangDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0001-5440-1414

Funding

Cellular homeostasis pathways in bacteriaR35GM118061 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, CAROL ANNE · 2016 to 2025
$9.0M
NIGMS NIH HHS R35 GM118061
6 · The paper itself

Abstract

Temperature shifts impose broad physiological stress, requiring precise and dynamic regulatory programs to restore cellular homeostasis. While the heat shock response is well characterized, the mechanisms underlying cold shock response (CSR) remain less understood. To identify genes critical for cold adaptation, we applied transposon sequencing (Tn-seq) to monitor mutant fitness across the full course of CSR and sustained low-temperature growth in two mesophilic bacteria,

Indexed as

Cell envelopeCold shock responseRNA metabolismTn-seqTranslation

Identifiers

PMID41040150
PMCPMC12485807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.