Evidence map›Paper›PMID 41040143›Full record

ArticlebioRxiv : the preprint server for biology2025

Madeline P Marques, Bo Sun, Ye-Jin Park, Tyler Jackson, Tzu-Chiao Lu, Yanyan Qi, Erin Harrison, Miranda C Wang, Kartik Venkatachalam, Omar Moussa Pasha and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2026
5 · Who and what money

Authors and funding

22 authors.

Madeline P MarquesHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Bo SunHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Ye-Jin ParkHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Tyler JacksonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Tzu-Chiao LuHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Yanyan QiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Erin HarrisonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Miranda C WangHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Kartik VenkatachalamDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Omar Moussa PashaHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Amogh VaranasiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Dominique Kiki CareyThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
D R ManiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Jonathan ZirinDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Mujeeb QadiriDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Steven A CarrThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Namrata D UdeshiThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Jiefu LiJanelia Research Campus, HHMI, Ashburn, VA 20147.
Hongjie LiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
TRiP resources for modeling human diseaseR24OD030002 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2020 to 2023
$3.2M
Next-generation Drosophila cell lines to elucidate the cellular basis of human diseasesR24OD019847 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT, SIMCOX, AMANDA · 2017 to 2020
$2.7M
Interorgan communication in aging in DrosophilaU01AG086143 · NIA · HARVARD MEDICAL SCHOOL · PI Hongjie Li, NORBERT PERRIMON · 2024 to 2026
$2.0M
Systematic Brain-Body Communication and Personalized Aging TrajectoriesDP2AT013275 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI LI, HONGJIE · 2024 to 2024
$1.4M
Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesR01AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2025 to 2025
$383k
NOVEL DROSOPHILA TRANSCRIPTION FACTOR ORTHOLOG OF BCL11A/BCL11B IS CRUCIAL FOR REGULATING INTESTINAL STEM CELL QUIESCENCE AND PREVENTING GUT DYSFUNCTION DURING AGINGF31DK141194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Tyler Jackson · 2025 to 2026
$100k
NCCIH NIH HHS DP2 AT013275NIA NIH HHS R01 AG069076NIA NIH HHS U01 AG086143NIDCD NIH HHS R01 DC005982NIDDK NIH HHS F31 DK141194NIH HHS R24 OD019847NIH HHS R24 OD030002
6 · The paper itself

Abstract

Much focus has shifted towards understanding how glial dysfunction contributes to age-related neurodegeneration due to the critical roles glial cells play in maintaining healthy brain function. Cell-cell interactions, which are largely mediated by cell-surface proteins, control many critical aspects of development and physiology; as such, dysregulation of glial cell-surface proteins in particular is hypothesized to play an important role in age-related neurodegeneration. However, it remains technically difficult to profile glial cell-surface proteins in intact brains. Here, we applied a cell-surface proteomic profiling method to glial cells from intact brains in

Indexed as

agingDIP-βDrosophilagliain-situ cell-surface proteomicssnRNA-seq

Identifiers

PMID41040143
PMCPMC12485902

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.