Evidence map›Paper›PMID 41040062›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2025

Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual-Tracer Positron Emission Tomography Imaging Study.

Faranak Ebrahimian Sadabad, Tommaso Volpi, Praveen Honhar, Sule Tinaz, Mark Dias, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Yanghong Yang, Waleed Ibrahim and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Faranak Ebrahimian SadabadDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-6649-7211
Tommaso VolpiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-5451-6710
Praveen HonharDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-9073-6270
Sule TinazDepartment of Neurology, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2220-8278
Mark DiasDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Yanghong YangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Waleed IbrahimDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Brian PittmanDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Salih CayirDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-4071-5188
Rajiv RadhakrishnanDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Gustavo A AngaritaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Sophie E HolmesDepartment of Neurology, Yale University, New Haven, CT, USA.
Robert ComleyAbbVie, North Chicago, IL, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Sjoerd J FinnemaAbbVie, North Chicago, IL, USA.
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.

Funding

Depression and accelerated brain aging: A PET imaging studyR01MH118728 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA, PIETRZAK, ROBERT H · 2019 to 2024
$5.6M
Do hippocampal synaptic density deficits in cannabis use disorder improve following abstinence?R01DA054314 · NIDA · YALE UNIVERSITY · PI D'SOUZA, DEEPAK CYRIL, ESTERLIS, IRINA · 2021 to 2025
$2.8M
In vivo synaptic and dopamine transporter imaging in Parkinson's diseaseR01NS124819 · NINDS · YALE UNIVERSITY · PI DAVID A MATUSKEY · 2022 to 2026
$2.7M
Multimodal imaging of depression in Parkinson's diseaseR21NS120116 · NINDS · YALE UNIVERSITY · PI HOLMES, SOPHIE · 2021 to 2021
$461k
NIDA NIH HHS R01 DA054314NIH HHS 1R01NS124819NIH HHS R21DA054314-01NIH HHS R21NS120116NIMH NIH HHS R01 MH118728NINDS NIH HHS R01 NS124819NINDS NIH HHS R21 NS120116
6 · The paper itself

Abstract

background

objectiveTo evaluate similarities and differences between patterns of DAT and SV2A binding in healthy controls (HC) and PD patients at different disease stages.

methodsThirty patients with PD (12 women, age: 65.8 ± 7.1 years) and thirteen HCs (7 women, age: 57.8 ± 5.4 years) underwent PET imaging with

resultsIn HCs, significant correlations were observed between caudate

conclusionsThis study examined the relationship between DAT and overall synaptic density in nigrostriatal ROIs in PD using dual-tracer PET imaging, and there were distinct patterns that vary across disease stages. Understanding the interplay between dopaminergic and presynaptic degeneration in PD could enhance our knowledge of its pathophysiology and contribute to improve diagnosis. © 2025 International Parkinson and Movement Disorder Society.

Indexed as

Dopamine Plasma Membrane Transport ProteinsParkinson DiseasePositron-Emission TomographySynapsesAgedFemaleHumansMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsSubstantia NigraDopamine Plasma Membrane Transport ProteinsMembrane GlycoproteinsNerve Tissue ProteinsSV2A protein, humandopaminePDPETSV2A

Identifiers

PMID41040062
PMCPMC13394740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.