Evidence map›Paper›PMID 41040059›Full record

ArticleProteins2026

The RNA-Puzzles Assessments of RNA-Only Targets in CASP16.

Eric Westhof, Hao Sun, Fan Bu, Zhichao Miao

Abstract read
In one paragraph

Article in Proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. ProNA3D: Distance-Based Analysis of Nucleic Acid-Containing Interfaces.Computational and structural biotechnology journal · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Assessment of nucleic acid structure prediction in CASP16.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eric WesthofArchitecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg, Strasbourg, France.ORCID 0000-0002-6172-5422
Hao SunGuangzhou National Laboratory, Guangzhou, Guangdong, China.
Fan BuGuangzhou National Laboratory, Guangzhou, Guangdong, China.
Zhichao MiaoGuangzhou National Laboratory, Guangzhou, Guangdong, China.

Funding

Major Projects of Guangzhou National Laboratory GZNL2023A01006Major Projects of Guangzhou National Laboratory GZNL2024A01002Major Projects of Guangzhou National Laboratory GZNL2025C01007Major Projects of Guangzhou National Laboratory HWYQ23-003Major Projects of Guangzhou National Laboratory YW-YFYJ0102National Key R&D Programs of China 2023YFF1204700National Key R&D Programs of China 2024YFF1206600Wenzhou Institute of Biomaterials and EngineeringWenzhou Institute, University of Chinese Academy of Sciences WIUCASQD2024002
6 · The paper itself

Abstract

RNA-Puzzles was launched in 2011 as a collaborative effort dedicated to advancing and improving RNA 3D structure prediction. The automatic evaluation protocols for comparisons between prediction and experiment developed within RNA-Puzzles are applied to the 2024 CASP16 competition. The scores evaluate stereochemical parameters, Watson-Crick pairs, non-Watson-Crick pairs, and base stacking in addition to standard global parameters such as RMSD, TM-score, GDT, or lDDT. Several targets were particularly difficult owing to their size or multimerization. As noted in previous evaluations, although predictions that perform well on secondary structure may also achieve acceptable overall folds, they are insufficient to guarantee chemical precision or to correctly identify residues involved in non-Watson-Crick interactions. Both are essential for obtaining a valid three-dimensional architecture and for understanding the biological function of RNAs.

Indexed as

Computational BiologyNucleic Acid ConformationRNASoftwareBase PairingModels, MolecularRNA3D predictionmodelingRNARNA architectureRNA‐Puzzles

Identifiers

PMID41040059
PMCPMC12750035

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.