Evidence map›Paper›PMID 41039949›Full record

ArticleHistology and histopathology2026

Comparable expression of stem markers and damage-responsive proteins in untreated and chemoradiation-treated rectal cancer.

Kentaro Tsuji, Sachi Sekine, Hirotoshi Kawata, Tomoko Kamiakito, Takeo Nakaya, Yasuyuki Miyakura, Koichi Suzuki, Toshiki Rikiyama, Akira Tanaka

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kentaro Tsuji *Division of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Sachi Sekine *Division of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Hirotoshi KawataDivision of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Tomoko KamiakitoDivision of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Takeo NakayaDivision of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Yasuyuki MiyakuraDeparment of Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Koichi SuzukiDeparment of Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Toshiki RikiyamaDeparment of Surgery, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Akira TanakaDivision of Human Pathology, Department of Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan. atanaka@jichi.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer stem cells (CSCs) are suggested to contribute to therapy resistance in rectal cancer. However, histopathological analysis of CSCs is still lacking in rectal cancer.

methodsThe expression of leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5), proto-oncogene, polycomb ring finger 1 (BMI1), yes-associated transcriptional regulator (YAP) and its paralog TAZ (hereafter, YAP/TAZ), and nuclear β-catenin was compared in untreated and chemoradiation-treated (CRT) rectal cancer by

resultsThe mean ratios were 15% and 14% for LGR5, 30% and 33% for BMI1, 2.7% and 7.6% for YAP/TAZ, and 38% and 32% for nuclear β-catenin in untreated and CRT rectal cancer, respectively, showing no significant differences for these stem markers following CRT. The stromal expression ratios of YAP/TAZ were 9.7% and 23% in untreated and CRT rectal cancer, which indicated significant upregulation and confirmation of the damage response in the stroma of CRT tumors. In addition, cancer cells co-expressing LGR5 and CDKN1B are also comparable in untreated and CRT rectal cancer. For niche factors, we found that WNT2B and GREM1 were uniformly expressed in rectal cancer with a pattern similar to that of the early embryonic intestine.

conclusionThe expression of LGR5, BMI1, CDKN1B, and YAP/TAZ was comparable in untreated and CRT rectal cancer. The uniform expression of mesenchymal niche factors might prevent the zonation of the stem cell niche in rectal cancer.

Indexed as

Biomarkers, TumorNeoplastic Stem CellsRectal NeoplasmsAdaptor Proteins, Signal TransducingAdultAgedbeta CateninChemoradiotherapyFemaleHumansMaleMiddle AgedPolycomb Repressive Complex 1Proto-Oncogene MasReceptors, G-Protein-CoupledTrans-ActivatorsAdaptor Proteins, Signal Transducingbeta CateninBiomarkers, TumorBMI1 protein, humanLGR5 protein, humanMAS1 protein, humanPolycomb Repressive Complex 1Proto-Oncogene MasReceptors, G-Protein-CoupledTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID41039949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.