ArticleRenal failure2025
Exercise-mediated amelioration of high-fat diet-induced kidney injury: implications of microRNA regulation.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Apigenin Combined with Aerobic Exercise Is Associated with Attenuated Renal Oxidative Stress and AMPK/SIRT1/PGC-1α Pathway Activation in NAFLD Mice.Current issues in molecular biology · 2026Article
- Transcriptomic insights into aerobic exercise-mediated attenuation of high-fat diet-induced muscle wasting.Frontiers in physiology · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Obesity-related kidney injury has become a critical health concern, driven by metabolic disturbances, chronic inflammation, oxidative stress, and structural remodeling. While exercise is widely recognized for its broad health benefits, including its ability to mitigate obesity-related complications by improving metabolic homeostasis, reducing inflammation, and enhancing antioxidative capacity, its specific role in protecting renal function - particularly through the modulation of microRNAs (miRNAs) - remains insufficiently understood. This study investigated the effects of an 8-week moderate-intensity treadmill exercise intervention on high-fat diet (HFD)-induced kidney injury in a murine model. Chronic HFD feeding resulted in significant renal dysfunction, evidenced by elevated filtration markers (urinary total protein, urinary microalbumin, urinary creatinine, and serum creatinine) and injury biomarkers (neutrophil gelatinase-associated lipocalin, cystatin C, and kidney injury molecule 1), alongside structural abnormalities, such as glomerular hypertrophy, mesangial expansion, and fibrosis. These changes were accompanied by increased pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), heightened oxidative stress (elevated malondialdehyde, reduced glutathione, glutathione s-transferase, and superoxide dismutase), and dysregulation of several miRNAs, such as miR-150-5p and miR-182-5p, which are known to exacerbate renal injury. Exercise significantly alleviated the adverse effects of HFD by improving renal function, reducing structural damage, suppressing inflammation, enhancing antioxidative capacity, and downregulating miR-150-5p and miR-182-5p. These findings underscore the therapeutic potential of exercise in mitigating obesity-related kidney injury and provide novel insights into its renoprotective effects mediated by miRNA regulation.
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