ArticleThe journal of physical chemistry letters2025
Electron-Induced Fragmentation of 5-Iodouridine: Implications for Enhanced Radiotherapy.
Article in The journal of physical chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
5-Iodouridine is a known and potentially efficient radiosensitizer; however, it has not been considered for clinical use because of its poor metabolic incorporation into DNA. Recent development of a novel pro-drug, ropidoxuridine, has improved the bioavailability of this halogenated nucleoside, although the exact mechanism of its radiosensitizing action remains not fully elucidated. Here, we demonstrate that low-energy electrons─abundantly generated along radiation tracks─efficiently dissociate the halogenated nucleoside via the primary pathway (99%), producing an iodine anion and a uridine-yl
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