ArticlePediatric transplantation2025
Utilization of a Pediatric DCD Liver Following Normothermic Regional Perfusion: A Case Report on the Youngest Donor in the United States.
Article in Pediatric transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Expanding the Donor Pool in Pediatric Transplantations: Successful Domino Liver Transplantation From the Youngest Reported Pediatric DCD Donor Using Normothermic Regional Perfusion in the United States.Pediatric transplantation · 2026Article
- Utilization of a Pediatric DCD Liver Following Normothermic Regional Perfusion: A Case Report on the Youngest Donor in the United States.Pediatric transplantation · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundNormothermic regional perfusion (NRP) is gaining rapid popularity in adult donation after circulatory death (DCD) to increase organ utilization and improve outcomes. However, literature is lacking for the pediatric population. We therefore present the youngest DCD donor in the United States from whom a liver was recovered with NRP and subsequently transplanted.
methodsThe donor was a 5-year-old male who underwent thoraco-abdominal NRP for kidney and liver procurement. In total, 72 min passed from the withdrawal of life-sustaining treatment to the start of NRP, resulting in 10 min of functional warm ischemia time. The donor was perfused for 80 min, with lactate levels decreasing from 8.29 at the start of perfusion to 5.40 mmol/L at the end of perfusion. The procured graft weighed 480 g and was subsequently transplanted in an adult female recipient with decompensated cirrhosis due to alcohol-associated liver disease.
resultsThe liver was successfully utilized and functioned immediately with no graft-specific complications. The patient was discharged on postoperative day 39.
conclusionsThis case demonstrates that NRP can be applied effectively in small pediatric donors, yielding excellent early graft function. Our experience adds to the emerging literature on pediatric NRP. We conclude that broader adoption of NRP could help increase the donor pool and ease the strain on the pediatric waiting list.
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