ArticleCell & bioscience2025
The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway.
Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe oviduct (or fallopian tube) plays a functional role in the transportation of gametes and early-stage embryos, serving as a site for fertilization. Any aberrations from the normal functioning of fallopian tube epithelium may lead to diseases, including but not limited to infertility, ectopic pregnancy, and carcinoma. However, little is known about the mechanisms governing oviductal epithelial homeostasis between secretory cells and ciliated cells by miRNAs.
resultsIn this study, we found that the expression levels of miR-34b/c and miR-449a/b/c were positively correlated with the number of ciliated cells. Using the miR-34b/c
conclusionsIn summary, we discovered that ablation of miR-34/449 led to hyperactivation of the Wnt/β-catenin signaling pathway, which resulted in the differentiation impairment of ciliated cells, thus resulting in infertility in the mice. This study revealed a novel mechanism describing how miR-34/449 affects oviductal ciliated cell differentiation and oviductal epithelial homeostasis through the Wnt/β-catenin signaling pathway and finally affects fertility.
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