ArticleTropical medicine and health2025
Global, regional, and national childhood brain and central nervous system cancer burden: an analysis based on the Global Burden of Disease Study.
Article in Tropical medicine and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions.Children (Basel, Switzerland) · 2026Review
- Epidemiology of brain and central nervous system cancers in children and adolescents.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
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6 authors.
Funding
Abstract
objectivesWe assessed the global, regional, and national burdens of childhood brain and central nervous system cancer from 1990-2021 (the latest year).
methodsWe utilized data from the 2021 Global Burden of Disease Study and analyzed trends in childhood brain and central nervous system cancers through joinpoint regression. We assessed the global burden of childhood brain and central nervous system cancers from various perspectives. Finally, the Bayesian age‒period‒cohort model was employed to forecast future trends through 2030.
resultsChildhood brain and CNS cancers are the most common solid tumors and the leading cause of death in children. From 1990 to 2021, the age-standardized incidence, prevalence, mortality, and DALYs decreased. The incidence is slightly greater in boys than in girls and peaks at 0-4 years of age, decreasing with age. The disease burden correlates with sociodemographic indices, with higher burdens observed in regions with higher sociodemographic indices. Future projections indicate a continued decline in incidence, prevalence, mortality, and DALYs.
conclusionsWhile the global burden of childhood brain and CNS cancer has significantly decreased due to medical advancements, childhood cancer continues to be a major cause of childhood mortality. Further optimization of global health resources is crucial for alleviating this burden.
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