ArticleCancer & metabolism2025
Pressure-adjusted static compression: aerobic metabolism and microvascular perfusion in the context of chemotherapy-induced neuropathy.
Article in Cancer & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- In Vivo Extracellular Recording Reveals Bidirectional Changes in Neuronal Activity in the Rat Spinal Dorsal Horn After Hindlimb Ischemia-Reperfusion.International journal of molecular sciences · 2026Article
- Effectiveness of Compression Therapy for the Prevention of Taxane-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
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Authors and funding
10 authors.
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Abstract
backgroundChemotherapy-induced peripheral neuropathy (CIPN) involves impaired microvascular neuronal perfusion and reduced bioenergetics. Compression and cryotherapy are potential preventive measures, yet their mechanism of acral temperature reduction remains unclear. This study aims to unravel the effects of pressure-adjusted static compression (PSC) on aerobic metabolic and endothelial responses in patients undergoing chemotherapy (CTX).
methodsCancer patients with CTX above the CIPN-threshold dose (n = 24, 50% male; age 64 [61-71] years) and healthy controls (n = 53, 45% male; age 23 (18 to 87) years) had PSC applied on upper extremities. Tissue oxygenation and metabolism were derived by measuring oxygen supply (O
resultsPSC, in contrast to undersized surgical gloves (SG), uniformly creates pressure on hands and leads to a more pronounced reduction of hand temperature. Furthermore, PSC significantly increased microvascular perfusion, O
conclusionsReduction of oxygen demand represents an important mechanism in interventions targeting prevention of CIPN. PSC, comparable to cryoapplication and IPC attenuates energy metabolism and enhances tissue oxygenation. PSC's impact on the combination of vascular and energy metabolism suggests its potential to alleviate CIPN burden. These findings support PSC's role in reducing acral CIPN through distinct mechanisms.
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