ArticleBMC psychiatry2025
Spatiotemporal alterations of thalamo-cortical effective connectivity in major depressive disorder patients.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThalamic structural and functional abnormalities in major depressive disorder (MDD) are linked to impairments in diverse cognitive and emotional functions via the thalamo-cortical circuit. Given the constraints of temporal and spatial factors on information exchange, investigating frequency-specific effective connectivity (EC) is essential for elucidating the abnormal mechanisms of spatiotemporal information communication in patients with MDD.
methodWe employed a large-scale, multicenter resting-state functional magnetic resonance imaging (fMRI) dataset comprising individuals with MDD and matched healthy controls. Frequency-specific EC between the thalamic subregions and cortical/subcortical regions was assessed using spectral Granger causality in four frequency bands: slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.185 Hz), and a classic frequency range (0.01–0.08 Hz). Support vector regression (SVR) models were employed to evaluate the predictive value of altered EC for clinical symptom scores.
resultsIndividuals with MDD exhibited significant and frequency-dependent abnormalities in thalamocortical and thalamo-subcortical EC, with the most pronounced disruptions observed in the slow-5 band. These abnormalities originate from the specific thalamic subregions and extend to cortical and subcortical regions. Among the frequency bands analyzed, EC alterations in the slow-5 band showed the strongest association with clinical severity and yielded the highest predictive performance in SVR models.
conclusionsFrequency-specific EC disruptions, particularly within the slow-5 band, may reflect fundamental spatiotemporal communication deficits in MDD. These findings highlight the slow-5 thalamocortical and thalamo-subcortical EC as a potential neurobiological marker for diagnosis and a target for treatment strategies in MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.