Evidence map›Paper›PMID 41039427›Full record

ArticleBMC pediatrics2025

Effect of serum creatinine changes on surgical timing and prognosis in progressive necrotizing Enterocolitis.

JinBao Han, JianYing Cao, Gang Liu, Lian Duan, MengNan Yu, Guang Li, LiuMing Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

JinBao HanDepartment of Emergency Surgery, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China.
JianYing CaoDepartment of Neonatal Surgery, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.
Gang LiuDepartment of Neonatal Surgery, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.
Lian DuanDepartment of Neonatal Surgery, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.
MengNan YuDepartment of Neonatal Surgery, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.
Guang LiDepartment of Neonatal Surgery, Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.
LiuMing HuangDepartment of Emergency Surgery, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, 100045, China. surhlm@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo explore the effect of elevated serum creatinine on the timing of surgery and prognosis in patients with progressive necrotizing enterocolitis.

methodsA total of 367 children who underwent surgery for necrotizing enterocolitis(NEC) from May 2008 to April 2024 were collected, and 156 patients with incomplete data were excluded. Among the remaining 211 surgical cases, 168 patients (before August 14, 2019) were included in the statistical analysis, and 43 patients (after August 14, 2019) were used as the validation set. The basic data of the patients, including gender, gestational age, birth weight, age at onset, the length of ICU stay, cardiac ultrasound results, Bell's stage, whether they were small for gestational age, urine volume in the 24 h before operation, preoperative blood routine (white blood cells, platelets), C-reactive protein (CRP), blood gas analysis, renal function (serum creatinine, blood urea nitrogen) and weight at the time of surgery were collected for statistical analysis.

resultsA total of 98 (26.7%) patients died among the 367 patients, of which 47 (48%) had acute kidney injury. Between the 211 patients included in the statistical analysis, 47 (22.3%) died, and among the 168 patients in the data set, 39 (23.2%) died. Of the 43 patients in the validation set, 8 (18.6%) died. There were statistically significant differences in birth weight, length of ICU stay, preoperative serum creatinine, urine volume, white blood cell count, lactate, HCO3-, heart malformations, and small for gestational age status in the collected data, p < 0.05. After ROC-AUC analysis, it was found that when serum creatinine cutoff = 60.5ummol/L, the area under the curve AUC = 0.842, sensitivity = 0.795, specificity = 0.705, and after COX regression analysis, the serum creatinine HR value = 7.242, 95% CI [2.852-18.388]. Log Rank in the K-M curve of SGA = 42.958, p < 0.001. Among the 43 cases in the validation set, 35 survived, sensitivity = 0.75, specificity = 0.771.

conclusionIn addition to clinical manifestations, imaging, and infection indicators as factors for determining surgical indications in progressive NEC, more active intervention should be considered when serum creatinine begins to rise to 60.5ummol/L. LEVEL OF EVIDENCE: Level III Retrospective Comparative Cohort Study.

Indexed as

CreatinineEnterocolitis, NecrotizingTime-to-TreatmentAcute Kidney InjuryBiomarkersFemaleHumansInfantInfant, NewbornMalePrognosisRetrospective StudiesBiomarkersCreatinineAcute renal failureMortalityNeonatal necrotizing enterocolitisSerum creatinineSurgical treatment

Identifiers

PMID41039427
PMCPMC12492904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.