Evidence map›Paper›PMID 41039417›Full record

Observational studyBMC pediatrics2025

Preventing volume loss during extubation in preterm infants: a prospective observational study.

Leonie Plastina, Kaylen Gähwiler, Vincent D Gaertner, Andreas D Waldmann, Christoph M Rüegger, Dirk Bassler, Janine Thomann

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonie Plastina *Department of Neonatology, Newborn Research Zurich, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland. leonie.plastina@usz.ch.
Kaylen Gähwiler *Department of Neonatology, Newborn Research Zurich, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland.
Vincent D GaertnerDivision of Neonatology, Dr von Hauner Children's Hospital, LMU Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
Andreas D WaldmannDepartment of Anesthesiology and Intensive Care Medicine, Rostock University Medical Center, Rostock, Germany.
Christoph M RüeggerDepartment of Neonatology, Newborn Research Zurich, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland.
Dirk BasslerDepartment of Neonatology, Newborn Research Zurich, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland.
Janine ThomannDepartment of Neonatology, Newborn Research Zurich, University Hospital Zurich, Frauenklinikstrasse 10, Zurich, 8091, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to minimize interruptions in positive end-expiratory pressure (PEEP) delivery.

methodsThis was a prospective observational study including preterm infants born before 32 weeks' gestation who underwent elective extubation without conditions negatively impacting lung aeration or perfusion. Participants were recruited at the University Hospital Zurich (June 2023-March 2024). We compared a novel extubation protocol that minimizes infant handling to a conventional protocol. Lung volume changes were continuously monitored noninvasively via electrical impedance tomography (EIT), capturing end-expiratory lung impedance (EELI) as a proxy for end-expiratory lung volume (EELV). The pulse rate (PR), oxygen saturation (SpO2), and inspired oxygen fraction (FiO

resultsFifteen extubations were analysed. At initiation of non-invasive ventilation (NIV), the median EELI decreased by -0.68 AU/kg (IQR: -0.99 to -0.21), reflecting a median EELV loss of 27.7 ml/kg (IQR: -40.6 to -8.6). The greatest EELI loss occurred during tape removal (-0.24 AU/kg, p

conclusionsWhile minimal handling did not prevent lung volume loss during extubation, a stabilization period preceding extubation facilitated partial lung volume restoration.

Indexed as

Airway ExtubationInfant, PrematureElectric ImpedanceFemaleHumansInfant, NewbornLung Volume MeasurementsMaleNoninvasive VentilationPositive-Pressure RespirationProspective StudiesTidal VolumeExtubationLung impedanceLung recruitmentPretermVentilation

Identifiers

PMID41039417
PMCPMC12492717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.