ArticleBMC public health2025
Socioeconomic development index (SDI) gradients and high BMI-Driven pan-cancer burden: a global burden of disease study on mortality, disability, and health inequities (2015-2021).
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Global observational analysis of the Quality of Care Index (QCI) for protein-energy malnutrition from 1990 to 2021.Medicine · 2026Observational
- Cancer burden among adults aged 65 years and older in Asia, 1990-2023: a systematic analysis of the Global Burden of Disease Study 2023.npj aging · 2026Article
- Clinical Significance and Potential Molecular Mechanisms of Angiotensin-Converting Enzyme 2 in Colorectal Cancer.World journal of oncology · 2026Article
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5 authors.
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Abstract
backgroundThe rising prevalence of high body mass index (BMI) has become a critical driver of global oncologic morbidity and mortality, yet its pan-cancer burden remains poorly characterized across socioeconomic development strata. This study investigates the geographic, temporal, and sex-specific disparities in high BMI-attributable cancer burden, stratified by the Socioeconomic Development Index (SDI), to inform precision public health strategies.
methodsLeveraging the 2021 Global Burden of Disease (GBD) dataset, we analyzed age-standardized mortality, disability-adjusted life years (DALYs), and years of life lost (YLLs) for 17-23 countries across Asia and globally. SDI-stratified analyses evaluated temporal trends (2015-2021) and cancer-type contributions, while multivariable models assessed associations between income inequality (Gini coefficient), healthcare capacity, and metabolic risk exposure.
resultsMarked disparities emerged across SDI gradients: high-SDI nations exhibited 6.7-fold higher mortality rates (e.g., Malaysia: 4.40 vs. Bangladesh: 0.65/100,000) and concentrated burdens in colorectal (40.5% DALYs) and breast cancers (27.0% DALYs), contrasting with distributed burdens in low-SDI regions (no cancer > 15.6% DALYs). Gender disparities highlighted male predominance in liver (+ 8.4 DALY difference) and colorectal cancers (+ 5.1), while female-specific malignancies (e.g., uterine cancer) retained consistent burdens across SDI levels. Temporal analyses revealed accelerated DALY reductions in middle-SDI regions (-4.5% annual percent change [APC]) but rising breast cancer burdens in low-SDI settings (+ 1.2% APC). Economic inequality (Gini > 0.40) correlated with elevated mortality (Turkey: 123.1/100,000), independent of GDP, underscoring synergistic impacts of BMI and sociodemographic inequities.
conclusionHigh BMI-driven pan-cancer burden is profoundly shaped by SDI gradients, reflecting interactions between metabolic risk, healthcare access, and socioeconomic determinants. Tailored interventions-prioritizing colorectal and breast cancers in high-SDI regions and addressing systemic inequities in low-SDI settings-are critical to mitigating the dual burden of obesity and cancer in transitioning populations.
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