Evidence map›Paper›PMID 41039380›Full record

ArticleBMC pediatrics2025

Survival status and predictors of mortality among thrombocytopenic neonates admitted at comprehensive specialized hospital neonatal intensive care units in East Amhara, Ethiopia, 2023 a multi-center prospective follow-up study.

Fekadeselassie Belege Getaneh, Endalk Birrie Wondifraw, Moges Workneh, Alemu Gedefie, Aden Asmare, Mohammed Tessema Gebeyehu, Markos Wodaje, Asressie Molla

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Fekadeselassie Belege GetanehCollege of Medicine and Health Sciences, Wollo University, P.O. box 1145, Dessie, Ethiopia. fekadebelege@gmail.com.ORCID 0000-0001-8729-1784
Endalk Birrie WondifrawCollege of Medicine and Health Sciences, Wollo University, P.O. box 1145, Dessie, Ethiopia.
Moges WorknehCollege of Medicine and Health Sciences, Wollo University, P.O. box 1145, Dessie, Ethiopia.
Alemu GedefieCollege of Medicine and Health Sciences, Wollo University, P.O. box 1145, Dessie, Ethiopia.
Aden AsmareDessie Comprehensive Specialized Hospital, Dessie, Ethiopia.
Mohammed Tessema GebeyehuCollege of Health Sciences, Debre Birhan University, Debre Birhan, Ethiopia.
Markos WodajeCollege of Health Sciences, Dilla University, Dilla, Ethiopia.
Asressie MollaCollege of Medicine and Health Sciences, Wollo University, P.O. box 1145, Dessie, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombocytopenia, defined as a platelet count of less than 150 × 10

objectiveTo assess survival status and predictors of mortality among thrombocytopenic neonates admitted to comprehensive specialized hospital neonatal intensive care units (NICUs) in Ethiopia. METHODOLOGY: A multi-center, institution-based prospective follow-up study was conducted among 302 thrombocytopenic neonates admitted to NICUs in East Amhara, Ethiopia, from August 2022 to March 2023. The neonates were followed for up to 28 days, with data collected using a structured tool and analyzed using STATA software. Kaplan-Meier survival curves, log-rank tests, and Weibull regression were used to determine survival time differences and predictors of mortality, with statistical significance set at p < 0.05.

resultOverall, 21.9% (61/278) of the thrombocytopenic neonates died, and the median time to death was 22 days (IQR: 15, 28). Significant predictors for time to death of thrombocytopenic neonates were male sex [adjusted hazard ratio (AHR): 2.2; 95% CI: 1.19-4.04], birth weight (β: 0.99; 95% CI: 0.98-0.99), episode of thrombocytopenia (β: 1.16; 95% CI: 1.01-1.34), late-onset thrombocytopenia (AHR: 2.23; 95% CI: 1.01-4.55), necrotizing enterocolitis (AHR: 2.0; 95% CI: 1.04-3.85), and low 5th minute Apgar score (AHR: 2.03; 95% CI: 1.02-4.02).

conclusionThese findings highlight the association between the aforementioned factors and higher mortality rates in thrombocytopenic neonates, emphasizing the need for further research to understand the underlying mechanisms and develop effective interventions to improve outcomes.

Indexed as

Intensive Care Units, NeonatalThrombocytopeniaEthiopiaFemaleFollow-Up StudiesHumansInfant, NewbornMaleProspective StudiesRisk FactorsNeonatePredictorsThrombocytopeniaWeibull regression

Identifiers

PMID41039380
PMCPMC12492744

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