ArticleBMC psychiatry2025
The association between heart rate variability and inflammatory markers in first-episode depressed patients with different sleep quality.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The interaction between the immune system and the autonomic nervous system in the pathophysiology of major depressive disorder: a scoping review.Brain, behavior, & immunity - health · 2026Review
- From brain to heart: cognitive performance shapes exercise- induced cardiac autonomic trajectories in older adults.Frontiers in medicine · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
objectiveTo investigate the associations between systemic inflammatory markers and heart rate variability (HRV) parameters across different levels of sleep disturbance in patients with first-episode depression.
methodsA total of 76 patients with first-episode moderate-to-severe depression and 30 healthy controls were enrolled. Patients were stratified into three groups based on Pittsburgh Sleep Quality Index (PSQI) scores: low (LSD), moderate (MSD), and severe (SSD) sleep disturbance. Peripheral inflammatory markers and 24-hour HRV parameters were measured. Partial Spearman correlation analyses were performed adjusting for age, sex, BMI, smoking status, and alcohol consumption.
resultsSignificant group differences were observed in inflammatory markers (IL-6, IL-1β, TNF-α, CRP, ESR) and parasympathetic-related HRV indices (SDANN, SDNN, HF), with the SSD group exhibiting the most pronounced alterations (all FDR-adjusted p < 0.05). Moreover, significant negative correlations between inflammatory markers and HRV parameters were detected only in the SSD group after covariate adjustment.
conclusionThe interaction between systemic inflammation and autonomic dysfunction appears to vary with sleep disturbance severity in depression. These findings highlight the importance of considering sleep disturbance stratification when evaluating physiological alterations in depressive disorders. Further studies are needed to clarify the underlying mechanisms and potential clinical implications of these associations.
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