Trial reportBMC infectious diseases2025
Effect of antibiotic prophylaxis after flexible cystoscopy to prevent symptomatic urinary tract infection: a randomized controlled trial.
Trial report in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSymptomatic urinary tract infection (UTI) is a common complication of flexible cystoscopy. Although the European Association of Urology (EAU) and the American Urological Association (AUA) do not recommend routine antibiotic prophylaxis for patients without risk factors, a survey revealed that over 90% of urologists at King Chulalongkorn Memorial Hospital (KCMH) and approximately 60% of Thai urologists routinely prescribe antibiotics for all cystoscopy patients, even those at low risk. This study aimed to examine the necessity of antibiotic prophylaxis following flexible cystoscopy in Thailand. MATERIALS AND
methodsA singlecenter, parallelgroup, randomized controlled noninferiority trial was conducted between August 2024 and January 2025 at the outpatient cystoscopy unit of KCMH, Bangkok, Thailand. A total of 284 patients without UTI risk factors were enrolled and randomly assigned to receive either cefixime or no antibiotics. UTI symptoms were assessed via telephone on day 7 postprocedure. The primary outcome was the incidence of postcystoscopy UTI symptoms, to assess noninferiority compared to those who received antibiotics. The secondary outcome was the overall prevalence of UTI following flexible cystoscopy at KCMH.
resultsOf the 284 enrolled patients, 265 completed the study. UTI symptoms occurred in 3.85% of the antibiotic prophylaxis group was not inferior to 5.93% of the noantibiotic group. 13 patients (4.9%) with UTI symptoms were successfully managed with oral antibiotics.
conclusionsRoutine antibiotic prophylaxis after flexible cystoscopy may be omitted in lowrisk patients. These findings support current EAU/AUA guidelines, which do not recommend prophylaxis for uncomplicated cystoscopy.
trial registrationTCTR20250402004 on 2 April 2025 (Retrospectively registered).
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