SynthesisBMC pediatrics2025
Probiotics for pediatric diarrhea and constipation: an umbrella meta-analysis.
Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Long-term safety and clinical effects of probiotic supplementation in at-risk populations: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current evidence regarding the impact of probiotics on diarrhea and constipation outcomes in children is inconclusive. This umbrella review of systematic reviews and meta-analyses aims to deliver a comprehensive and conclusive summary of the effectiveness of probiotics in managing these conditions in pediatric populations.
methodsMeta-analyses were collected from Scopus, PubMed, Embase, and the Web of Science until May 2025. The overall effect size was calculated using a random effect model.
resultsThis umbrella study comprises a systematic review of 35 studies. Our findings illustrated that probiotics reduce diarrhea incidence (ES = 0.52; 95% CI: 0.40, 0.68, P < 0.001; I2 = 91.2%, p < 0.001) compared to the control group, meaningfully. Also, it is successful in reducing diarrhea duration (WMD = -1.85; 95% CI: -2.83, -0.86, P < 0.001; I
conclusionsThis meta-analyses highlights the potential benefits of probiotics in improving diarrhea outcomes in children, demonstrating a reduction in both the incidence and duration of diarrhea following probiotic supplementation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.