Evidence map›Paper›PMID 41039201›Full record

ArticleBMC microbiology2025

Virulence factors of Candida spp. isolated from COVID-19 patients: hydrolytic enzyme activity and biofilm formation.

Ahmad Jabrodini, Somayeh Yazdanpanah, Mina Malekzadeh, Shafigheh Shabanzadeh, Maryam Ahmadyan, Keyvan Pakshir, Kamiar Zomorodian

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In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmad JabrodiniDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Somayeh YazdanpanahDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mina MalekzadehDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shafigheh ShabanzadehDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryam AhmadyanStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Keyvan PakshirDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Kamiar ZomorodianDepartment of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. zomorodian@sums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the coronavirus disease 2019 (COVID-19) pandemic, an increased prevalence of Candida co-infections has been reported. However, data on the virulence factors of Candida spp. isolated from COVID-19 patients remain scarce. This study aimed to assess the virulence factors of Candida spp. isolated from COVID-19 patients and to explore their potential associations with clinical parameters. A total of 71 Candida (C.) strains were analyzed, representing four species: 49 (69.01%) C. albicans strains, 14 (19.71%) C. glabrata strains, 7 (9.85%) C. tropicalis strains, and 1 (1.40%) C. dubliniensis strain. The activities of proteinase, phospholipase, and hemolysin, as well as biofilm-forming capacity, were evaluated. All C. albicans strains and 21 (95.45%) non-albicans Candida (NAC) strains produced proteinase. Phospholipase activity was detected in 46 (93.87%) C. albicans strains and 10 (45.45%) NAC strains. High hemolytic activity was observed in all Candida strains. Biofilm formation was detected in 31 (43.66%) Candida strains, with variable intensities. These findings highlight high levels of hydrolytic enzyme activity among Candida spp. isolated from COVID-19 patients and contribute to the growing understanding of Candida pathogenesis in immunocompromised populations, providing insights for patient management.

Indexed as

BiofilmsCandidaCandidiasisCOVID-19Virulence FactorsCoinfectionFemaleHemolysin ProteinsHumansMaleMiddle AgedPandemicsPeptide HydrolasesPhospholipasesSARS-CoV-2Hemolysin ProteinsPeptide HydrolasesPhospholipasesVirulence FactorsBiofilmCandidaCOVID-19HemolysinPhospholipaseProteinase

Identifiers

PMID41039201
PMCPMC12492772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.