Evidence map›Paper›PMID 41039169›Full record

ArticleJournal of neurology2025

Idiopathic intracranial hypertension and Ehlers-Danlos syndrome: a case series.

Isha V Ingle, David F Santos Malave, Gabrielle Bonhomme

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In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isha V IngleDepartment of Ophthalmology, University of Massachusetts, 281 Lincoln St, Worcester, MA, 01605, USA. isha.ingle@umassmemorial.org.
David F Santos MalaveDepartment of Ophthalmology, University of Massachusetts, 281 Lincoln St, Worcester, MA, 01605, USA.
Gabrielle BonhommeDepartment of Neuro-Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEhlers Danlos syndrome (EDS) is a group of 13 heritable connective tissue disorders with various ophthalmic manifestations. Idiopathic intracranial hypertension (IIH) is the presence of raised intracranial pressure (ICP) without specific neurological disease and deficits along with normal neuroimaging. The relationship between EDS and IIH has not been evaluated. In this report, we present a series of three confirmed cases of EDS with features of IIH. CASE SERIES: Case 1 was a 23 year old female patient with EDS who presented with intractable headaches. Her lumbar puncture (LP) had an elevated opening pressure of 53 cm H

conclusionThis is the largest series of cases linking IIH to EDS. Hyperextensibility may make meninges more pliable and tolerant to raised ICP. There may be a potential association between IIH and EDS, and IIH may be considered as one of the rare manifestations of EDS.

Indexed as

Ehlers-Danlos SyndromePseudotumor CerebriAdultFemaleHumansMagnetic Resonance ImagingMiddle AgedTomography, Optical CoherenceYoung AdultEhlers-Danlos syndromeIdiopathic intracranial hypertensionIntracranial pressureNeurologyOphthalmology

Identifiers

PMID41039169

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.