Evidence map›Paper›PMID 41039164›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Surgical management of raised ICP in craniosynostosis: experience-based selection of posterior vault expansion techniques.

Amparo Saenz, Andrea Allen-Tejerina, Alexandra Didi Leslie-Pyke, Luke Smith, Silvia Schievano, Adikarige Haritha Dulanka Silva, Greg James, David Dunaway, Juling Ong, Owase Jeelani

Abstract read
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amparo SaenzPediatric Neurosurgery Department, Great Ormond Street Hospital, London, UK. amparo.saenz@ucl.ac.uk.
Andrea Allen-TejerinaFace Value Research Group, Great Ormond Street Hospital, London, UK.
Alexandra Didi Leslie-PykeFace Value Research Group, Great Ormond Street Hospital, London, UK.
Luke SmithFace Value Research Group, Great Ormond Street Hospital, London, UK.
Silvia SchievanoFace Value Research Group, Great Ormond Street Hospital, London, UK.
Adikarige Haritha Dulanka SilvaPediatric Neurosurgery Department, Great Ormond Street Hospital, London, UK.
Greg JamesPediatric Neurosurgery Department, Great Ormond Street Hospital, London, UK.
David DunawayPediatric Neurosurgery Department, Great Ormond Street Hospital, London, UK.
Juling OngCraniofacial Unit, Great Ormond Street Hospital, London, UK.
Owase JeelaniPediatric Neurosurgery Department, Great Ormond Street Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate outcomes of three posterior vault expansion (PVE) techniques in children with craniosynostosis and confirmed raised intracranial pressure (ICP) and propose a practical framework to guide surgical technique selection based on patient-specific characteristics.

methodsWe retrospectively analyzed 116 pediatric patients who underwent their first PVE for confirmed raised ICP between January 2018 and January 2024 at a tertiary craniofacial center. Patients underwent one of three surgical techniques: static remodeling (PVE-S), spring-assisted posterior vault expansion-classic (SAPVE-C), or spring-assisted posterior vault expansion-vertical vector (SAPVE-VV). Outcomes included functional improvement (fundoscopy, VEPs, symptoms, Chiari I), volumetric change in intracranial volume (ICV), operative time, transfusion rates, complications, and reoperation-free survival. Analyses were stratified by age and syndromic diagnosis.

resultsAll techniques significantly improved functional markers, with complete resolution of papilledema and normalized VEPs in over 80% of patients. SAPVE-C and SAPVE-VV achieved greater increases in ICV compared to PVE-S (18.9% and 17.2% vs. 12.7%, respectively). SAPVE-C was fastest (mean 138 min), followed by SAPVE-VV (174.7 min) and PVE-S (214.5 min). Transfusion rates were highest in SAPVE-C (64.1%) and SAPVE-VV (60.5%). Reoperation occurred in 11.2% of patients, with significantly higher risk in those operated before age 1 (p = 0.04). Age-stratified outcomes revealed SAPVE-C achieved the highest volumetric gain in < 2 years, while SAPVE-VV was most effective in older patients.

conclusionsEach PVE technique offers distinct advantages. SAPVE-C is optimal for syndromic infants, SAPVE-VV provides volumetric control in complex cases across ages, and PVE-S remains effective for older, non-syndromic patients. A tailored, age- and diagnosis-based selection strategy is essential for optimizing outcomes in craniosynostosis-related raised ICP.

Indexed as

CraniosynostosesIntracranial HypertensionNeurosurgical ProceduresAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTreatment OutcomeCraniosynostosisElevated intracranial pressurePediatricSurgical outcomes

Identifiers

PMID41039164
PMCPMC12491112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.