ArticleNature biomedical engineering2026
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.
Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Multifunctional material platforms for neural interfaces: active orchestration of dynamic foreign body response across implantation lifetimes.Bioactive materials · 2026Review
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- High-channel-count neural recording and stimulation platform with 5376 simultaneous recording channels.npj biomedical innovations · 2026Article
- Injectable Antifouling Adhesive Hydrogel Enables Robust Neural Interfaces for Stable ECoG Recording.Advanced healthcare materials · 2026Article
- Advancing data protections for implantable brain-computer interfaces.Communications medicine · 2026Review
- Reversible Thermoactuation Unlocks Minimally Invasive Implantation and Retrieval of Soft Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Long-term unsupervised recalibration of cursor-based intracortical brain-computer interfaces using a hidden Markov model.Nature biomedical engineering · 2026Article
- Electronics with switchable flexibility for 3D conforming neural interfaces.Science advances · 2026Article
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- An artefact-resilient wide bandwidth bidirectional graphene neural interface.Nature communications · 2026Article
- Bridging the Gap: Integrated High-Density Microelectrode Arrays for Cellular, Organoid, and Clinical Electrophysiology.Micromachines · 2026Review
- Microscale organization and separability of upper extremity representations in the human motor homunculus.Research square · 2026Article
- High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels.bioRxiv : the preprint server for biology · 2026Article
- Brain-Computer Interfaces for Vision Recovery in Precortical Vision Loss.Eye and brain · 2026Review
- Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Review
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical delivery that avoids craniotomy in porcine models and cadavers. We show recording and stimulation from the same electrodes to large portions of the cortical surface, and the reversibility of delivering the implants to multiple functional regions of the brain without damaging the cortical surface. We evaluate the performance of the interface for high-density neural recording and visualizing cortical surface activity at spatial and temporal resolutions and total spatial extents. We demonstrate accurate neural decoding of somatosensory, visual and volitional walking activity, and achieve focal neuromodulation through cortical stimulation at sub-millimetre scales. We report the feasibility of intraoperative use of the device in a five-patient pilot clinical study with anaesthetized and awake neurosurgical patients, characterizing the spatial scales at which sensorimotor activity and speech are represented at the cortical surface. The presented neural interface demonstrates the highly scalable nature of micro-electrocorticography and its utility for next-generation brain-computer interfaces.
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Registered trials
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