Evidence map›Paper›PMID 41039037›Full record

ArticleScientific reports2025

Exploration of isolated actives from Coleus amboinicus leaves as anticancer agents: in vitro testing, network pharmacology studies, and molecular docking.

Kasta Gurning, Yehezkiel Steven Kurniawan, Friska Septiani Silitonga, Gian Primahana, Endang Astuti, Winarto Haryadi

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kasta GurningDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta, Yogyakarta, Indonesia.
Yehezkiel Steven KurniawanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta, Yogyakarta, Indonesia.
Friska Septiani SilitongaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta, Yogyakarta, Indonesia.
Gian PrimahanaNational Research and Innovation Agency (BRIN), Research Center for Pharmaceutical Ingredients and Traditional Medicine, South Tangerang, Indonesia.
Endang AstutiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta, Yogyakarta, Indonesia.
Winarto HaryadiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada Yogyakarta, Yogyakarta, Indonesia. wnrt_haryadi@ugm.ac.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is one of the serious health problems and is a major cause of death worldwide. Therefore, the development of anticancer agents is urgently needed. A potential and novel anticancer agent was successfully isolated from Coleus amboinicus (C. amboinicus) leaves (16-hydroxy-7α-acetoxyroyleanone compound). This study aims to explore the cytotoxic activity of the isolated compound against various cancer cells in vitro, network pharmacology studies on pathways in cancer, and molecular docking. Cytotoxicity testing using the tetrazolium microculture technique (MTT test) against MCF-7, A549, HeLa, and Du-145 cancer cell lines and the normal cell line (CV-1). Network pharmacology studies were carried out using bioinformatics with a database focused on three main proteins in the pathway in cancer and molecular docking was carried out computationally. The cytotoxic activity (IC

Indexed as

Antineoplastic AgentsAntineoplastic Agents, PhytogenicPlant ExtractsPlant LeavesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMolecular Docking SimulationNetwork PharmacologyAntineoplastic AgentsAntineoplastic Agents, PhytogenicPlant ExtractsBreast cancerCervical cancerColeus amboinicusNSCLCPathway in cancerProstate cancer

Identifiers

PMID41039037
PMCPMC12491499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.