ArticleScientific reports2025
Early extubation effects on postoperative outcomes in high-risk abdominal surgery based on propensity score matching.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes of early vs. late extubation following cardiac surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Deep extubation versus no-touch awake extubation in adults undergoing elective laparotomy: A randomised controlled trial.Indian journal of anaesthesia · 2026Article
- Prediction of postoperative pulmonary complications in geriatric patients with hip fracture using a nomogram incorporating bedside ultrasonography and clinical parameters.BMC geriatrics · 2026Observational
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Abstract
It is unclear whether Early Extubation (EE) practices affect the patient outcomes after Acute High-risk Abdominal (AHA) surgery. This study aims to explore the impact of EE on the postoperative prognosis of AHA surgery patients. A screening and analysis were performed among 9219 patients who underwent AHA surgery from January 2012 to December 2019. After meeting the pre-determined extubation criteria, patients were divided into two groups: EE (≤ 4 h) and Delayed Extubation (DE) (< 4 h) according to the time of extubation. Various clinical indicators were compared between the EE and DE groups after propensity-score matching. Hospital stay was the primary outcome assessed. And multivariate and subgroup analyses were performed to identify independent predictors of hospital stay length. After propensity-score matching, a total of 1074 patients were enrolled, including 537 in the EE group and 537 in the DE group. A greater number of DE patients underwent laparotomy and used vasoactive drugs than EE patients (p < 0.001). Compared to the DE group, the EE group had significantly shorter intubation time (285 [IQR 225, 350] vs. 427[IQR 300, 514]), lower postoperative pulmonary infection rates, and considerably shorter hospital stay (12 [IQR 10, 16] vs. 14 [IQR 10, 19]) (p < 0.001). In stepwise multivariable analysis, EE status (BETA-2.075; 95%CI (-2.898, -1.217)) and postoperative pulmonary infection (BETA 0.401; 95%CI (-2.898, -1.217)) were identified as independent variables associated with a longer hospital stay. Furthermore, EE status were identified as independent variables associated with a longer hospital stay, in subgroups (various diagnosis, BMI and sex) analysis. Extubation within 4 h of meeting extubation criteria in AHA surgery was associated with improved postoperative outcomes, including reduced postoperative pulmonary infection, and a shorter hospital stay. However, prospective randomized controlled trials are needed to confirm the observed benefits and establish optimal timing for extubation.
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