Evidence map›Paper›PMID 41038946›Full record

ArticleScientific reports2025

Laser irradiation of human skin tissue after gold nanoparticles injection for thermal ablation processes - a combined experimental and numerical approach.

Marta Cecotka, Piotr Radomski, Paweł Ziółkowski, Agata Tymińska, Katarzyna Czerwiec, Jacek Zieliński, Yue Dong, Christian Rossner, Francesca Petronella, Magdalena Narajczyk and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Marta CecotkaFaculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Institute of Energy, Narutowicza 11/12, 80-233, Gdańsk, Poland.
Piotr RadomskiFaculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Institute of Energy, Narutowicza 11/12, 80-233, Gdańsk, Poland.
Paweł ZiółkowskiFaculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Institute of Energy, Narutowicza 11/12, 80-233, Gdańsk, Poland. pawel.ziolkowski1@pg.edu.pl.
Agata TymińskaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Katarzyna CzerwiecLaboratory of Tissue Engineering and Regenerative Medicine, Division of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Jacek ZielińskiDepartment of Oncologic Surger, Medical University of Gdańsk, Gdańsk, Poland.
Yue DongLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069, Dresden, Germany.
Christian RossnerLeibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069, Dresden, Germany.
Francesca PetronellaNational Research Council of Italy, Institute of Crystallography CNR-IC, Montelibretti Division, Area Territoriale di Ricerca di Roma 1 Strada Provinciale 35d, Montelibretti, 00010, Italy.
Magdalena NarajczykFaculty of Biology, Bioimaging Laboratory, University of Gdańsk, Gdańsk, Poland.
Jakub KarczewskiFaculty of Applied Physics and Mathematics, Gdańsk University of Technology, Institute of Nanotechnology and Materials Engineering, Narutowicza 11/12, 80-233, Gdańsk, Poland.
Luciano De SioDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100, Latina, Italy.
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Dariusz MikielewiczFaculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Institute of Energy, Narutowicza 11/12, 80-233, Gdańsk, Poland.

Funding

Liebig fellowship Fonds der Chemischen IndustrieNational Science Centre in Poland UMO-2021/43/D/ST8/02504Politechnika Gdańska 13/1/2022/IDUB/II.1a/AuPolitechnika Gdańska 20/1/2024/IDUB/III.1a/RaPolitechnika Gdańska 42/1/2024/IDUB/III.4c/Tc
6 · The paper itself

Abstract

In recent years, investigation of new or combined therapeutic modalities for cancer treatment lead to relevant scientific advances. Among these innovative therapeutic modalities photothermal therapy (PTT) attracts attention as an alternative or complementary possibility to current anti-cancer treatments as it allows for the selective ablation of cancer cells. In the present study, PTT is investigated by using gold nanoparticles (AuNPs) as photothermal transducers. AuNPs are injected into human skin and used for PTT-assisted tumor ablation. The effectiveness of the PTT is evaluated as a function of AuNPs morphology, dimensions and the wavelength of the laser source. Five different laser sources with wavelengths ranging from 465 to 980 nm are used. The experimental findings point out that 808 and 980 nm are the optimal laser wavelengths for the PTT of human skin. Especially gold nanorods stabilized by poly(ethylene glycol) layer are identified as effective photothermal transducers. The experimental results are fully corroborated by numerical calculations. The outcomes emphasize the potential and the relevance of synthetically tailoring AuNPs particularly in optimizing their optical properties and assessing the effects of AuNP aggregation for specific applications.

Indexed as

GoldLaser TherapyMetal NanoparticlesPhotothermal TherapySkinHumansLasersGoldGold nanoparticlesHuman skinLaser irradiationPhoto-thermal ablation

Identifiers

PMID41038946
PMCPMC12491477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.