Evidence map›Paper›PMID 41038837›Full record

ArticleNature communications2025

Arabidopsis response to the apocarotenoid zaxinone involves interference with strigolactone signaling via binding to DWARF14.

Juan C Moreno, Umar F Shahul Hameed, Aparna Balakrishna, Abdugaffor Ablazov, Kit Xi Liew, Muhammad Jamil, Jianing Mi, Kawthar Alashoor, Alexandre de Saint Germain, Stefan T Arold and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Negative feedback regulation of karrikin signaling inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan C MorenoThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Umar F Shahul HameedPlant Science Program, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Aparna BalakrishnaThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Abdugaffor AblazovThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Kit Xi LiewThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Muhammad JamilThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.ORCID http://orcid.org/0000-0003-0221-518X
Jianing MiThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.ORCID http://orcid.org/0000-0001-7846-9472
Kawthar AlashoorThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Alexandre de Saint GermainUniversité Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), Versailles, France.ORCID http://orcid.org/0000-0003-2814-7234
Stefan T AroldPlant Science Program, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. Stefan.Arold@KAUST.edu.sa.ORCID http://orcid.org/0000-0001-5278-0668
Salim Al-BabiliThe Bioactives Laboratory, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. Salim.Babili@KAUST.edu.sa.ORCID http://orcid.org/0000-0003-4823-2882

Funding

King Abdullah University of Science and Technology (KAUST) CRG2020King Abdullah University of Science and Technology (KAUST) CRG2022King Abdullah University of Science and Technology (KAUST) REP/1/3842-01-01
6 · The paper itself

Abstract

The natural growth regulator zaxinone increases the levels of the phytohormones strigolactone (SL) and abscisic acid in Arabidopsis (Arabidopsis thaliana) via unknown mechanisms. Here we demonstrate that part of the effect of zaxinone in Arabidopsis depend on the SL receptor DWARF14 (AtD14) and the F-Box protein MORE AXILLARY BRANCHING2 (AtMAX2) that mediate the signaling of SLs and karrikins. Binding assays and co-crystallization reveal zaxinone as an additional ligand of AtD14 and an SL antagonist that interrupts the interaction of AtD14 with AtMAX2. Zaxinone also binds to the karrikin receptor KARRIKIN INSENSITIVE2 (AtKAI2). These findings unveil a perception mechanism for zaxinone in Arabidopsis and demonstrate the capability of AtD14 to bind signaling molecules, other than strigolactones and mediate their transduction.

Indexed as

ArabidopsisArabidopsis ProteinsHeterocyclic Compounds, 3-RingLactonesPlant Growth RegulatorsSignal TransductionFuransGene Expression Regulation, PlantProtein BindingPyransReceptors, Cell Surface3-methyl-2H-furo(2,3-c)pyran-2-oneArabidopsis ProteinsDWARF14 protein, ArabidopsisFuransHeterocyclic Compounds, 3-RingLactonesPlant Growth RegulatorsPyransReceptors, Cell Surface

Identifiers

PMID41038837
PMCPMC12491641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.