ArticleNature communications2025
Quantum-enhanced nanodiamond rapid test advances early SARS-CoV-2 antigen detection in clinical diagnostics.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global health preparedness for biosecurity threats: a review of emerging technologies and solutions.Frontiers in public health · 2026Pooled it
- Nitrogen-Vacancy Centers in Fluorescent Nanodiamonds: Emerging Applications from Healthcare Diagnostics to Semiconductor Metrology.Accounts of chemical research · 2026Article
- Evolution of Next-Generation Multiplex Lateral Flow Immunoassays: From Engineered Nanomaterials to AI-Driven Detection.Biosensors · 2026Review
- Sensitive and quantitative biosensing technique based on NV centres-doped nanodiamonds applied to lateral flow assays.Scientific reports · 2026Article
- Smartphone-based video deep learning enables rapid and accurate lateral flow diagnostics.Mikrochimica acta · 2025Article
- Quantum-enhanced nanodiamond rapid test advances early SARS-CoV-2 antigen detection in clinical diagnostics.Nature communications · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Quantum biosensors, which harness quantum effects to detect biomarkers, could address the urgent need for more sensitive rapid diagnostics. Lateral flow tests using nitrogen-vacancy centres in nanodiamond labels offer high sensitivity and robustness by controlling the spin-dependent fluorescence to remove background. This is particularly important in complex and variable clinical samples. However, to date only model systems have been studied with few clinical samples. Here we show results of a clinical evaluation of a spin-enhanced nanodiamond test for SARS-CoV-2 antigen with 103 upper respiratory tract swab samples. We find 95.1% sensitivity (Ct ≤ 30) and 100% specificity benchmarked against RT-qPCR, with no cross-reactivity to influenza A, RSV, and Rhinovirus. Modelling with patient data yields a mean of 2.0-days earlier detection compared to conventional gold-nanoparticle tests (just 0.6 days after RT-qPCR) with 2.2-fold more patients detected on the first day of symptom onset, potentially reducing the transmission risk and protecting populations.
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Registered trials
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