Evidence map›Paper›PMID 41038688›Full record

ArticleJournal of clinical periodontology2026

The Subgingival Host-Microbial Landscape in Mothers With Periodontitis and Their At-Risk Offspring.

Hélvis E S Paz, Camila S Stolf, Kai Bao, Mabelle F Monteiro, Lucas M Carvalho, Angelika Silbereisen, Georgios N Belibasakis, Renato C V Casarin, Nagihan Bostanci

Abstract read
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In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hélvis E S PazDivision of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brazil.ORCID 0000-0002-0619-2547
Camila S StolfDivision of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brazil.
Kai BaoDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Mabelle F MonteiroDivision of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brazil.ORCID 0000-0001-9333-4349
Lucas M CarvalhoPost Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, Brazil.ORCID 0000-0002-8766-0452
Angelika SilbereisenDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Georgios N BelibasakisDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Renato C V CasarinDivision of Periodontics, Department of Prosthodontics and Periodontics, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brazil.
Nagihan BostanciDivision of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6742-3556

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) 88887.717561/2022-00São Paulo Research Foundation (FAPESP) 2019/09740-3Steering Group KI/Region Stockholm for Dental Research (SOF) FoUI-966140Steering Group KI/Region Stockholm for Dental Research (SOF) FoUI-978687
6 · The paper itself

Abstract

aimTo evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases.

methodsForty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring. Periodontal clinical parameters were assessed. Gingival crevicular fluid (GCF) and subgingival biofilm were collected from the same sites. Proteome from GCF was investigated by liquid chromatography-tandem mass spectrometry with data-independent acquisition (DIA-PASEF). Bacterial DNA from subgingival biofilms was sequenced using the 16S rRNA gene for taxonomy assignment.

resultsOverall, 6147 bacterial and human proteins (≥ 2 peptides) were quantified. Despite the absence of attachment loss, the offspring of mothers with periodontitis presented with similar proteotypes as their mothers, characterised by up-regulation of inflammatory response cascades and down-regulation of epithelial barrier proteins. They also displayed higher colonisation patterns by periodontopathogens while presenting with increased expression of bacterial virulence proteins compared with controls.

conclusionThe study showed that the maternal periodontal microbiome and proteome associate with those of the offspring and relate to maternal periodontal status. These early ecological events may potentially promote offspring's susceptibility to dysbiosis and may predispose them to periodontitis.

Indexed as

GingivaMicrobiotaPeriodontitisAdultBiofilmsDysbiosisFemaleGingival Crevicular FluidHumansMaleMothersProteomeRNA, Ribosomal, 16SProteomeRNA, Ribosomal, 16Sdental plaquegingival crevicular fluidmicrobiomeperiodontitisproteomics

Identifiers

PMID41038688
PMCPMC12803676

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.