Evidence map›Paper›PMID 41038681›Full record

ArticleAsia Pacific journal of clinical nutrition2025

Causal association of dietary intake habits and telomere lengths: A Mendelian randomization study.

Jiahe Chen, Zhaoshuo Liu, Yang Nan, Haotian Liu, Ziqi Ren, Jianli Liu, Dan Liu, Ruiquan Qi

Abstract read
In one paragraph

Article in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiahe ChenSchool of Life Science, Liaoning University, Shenyang, China.
Zhaoshuo LiuSchool of Life Science, Liaoning University, Shenyang, China.
Yang NanSchool of Life Science, Liaoning University, Shenyang, China.
Haotian LiuSchool of Life Science, Liaoning University, Shenyang, China.
Ziqi RenSchool of Life Science, Liaoning University, Shenyang, China.
Jianli LiuSchool of Life Science, Liaoning University, Shenyang, China. Email: liujianli@lnu.edu.cn.
Dan LiuSchool of Life Science, Liaoning University, Shenyang, China.
Ruiquan QiSchool of Life Science, Liaoning University, Shenyang, China. Email: qiruiquan@lnu.edu.cn.

Funding

Liaoning Province science and technology plan joint project No. 2024-BSLH-102Natural Science Research Start-up Foundation for Doctors of Liaoning Province No. 2023-BS-089Program for Liaoning Provincial Department of Education No. LJ212410140093Scientific Research Fund of Liaoning Provincial Education Department No. LJKQZ20222359
6 · The paper itself

Abstract

BACKGROUND AND

objectivesHealthy diets are crucial in disease prevention and balanced diets can slow te-lomere shortening. Currently, it is still unclear which dietary factors are causally related to telomere length. METHODS AND STUDY

designThe inverse variance weighted, Mendelian Randomization-Egger, weighted median, simple mode, and weighted mode methods were used. Additionally, heterogeneity, pleiotropy, MR-PRESSO and leave-one-out tests were conducted to ensure accuracy. Outcomes included granulocyte, lym-phocyte, naive T-cell, memory T-cell, B-cell, and natural killer-cell telomere lengths. Exposures included alcohol intake frequency, alcoholic drinks per week, average weekly beer plus cider intake, average weekly red wine intake, intake of beef, bread, cereal, coffee, cooked vegetable, dried fruit, fresh fruit, lamb/mutton, non-oily fish, oily fish, pork, processed meat, salad/raw vegetable, tea and water.

resultsThe positive causal relationships were found between dried fruit intake and granulocyte telomere length (OR: 4.31; 95% CI: 1.29 to 14.4; p = 0.02), lymphocyte telomere length (OR: 4.22; 95% CI: 1.21 to 14.7; p = 0.02), naive T-cell telomere length (OR: 5.49; 95% CI: 1.58 to 19.0; p = 0.01). Oily fish intake was positively associated with memory T-cell telomere length (OR: 2.55; 95% CI: 1.16 to 5.58; p = 0.02). No significant causal relationships were found between other exposures and outcomes.

conclusionsThis study found positive causal associations between telomere length and the intake of dried fruit and oily fish. No significant causal relationships were observed with other dietary factors. These findings provide insights into how specific dietary components may help maintain telomere length.

Indexed as

DietFeeding BehaviorMendelian Randomization AnalysisTelomereTelomere HomeostasisTelomere ShorteningHumanscausal relationshipdietary factorshealthy diet referenceMendelian randomizationtelomere length

Identifiers

PMID41038681
PMCPMC12490951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.