ArticleAsia Pacific journal of clinical nutrition2025
Circulating vitamin D concentrations and the risk of urticaria: A bidirectional two-sample Mendelian randomization study.
Article in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Vitamin D and Chronic Urticaria: A Review of Potential Mechanisms, Clinical Evidence, and Future Directions.Dermatology research and practice · 2026Review
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5 authors.
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Abstract
BACKGROUND AND
objectivesVitamin D deficiency has been linked to urticaria, but causality remains uncer-tain. We used Mendelian randomization (MR) to investigate potential causal effects of vitamin D and its me-tabolites on urticaria risk. METHODS AND STUDY
designSummary statistics from genome-wide association studies (GWAS) of total 25-hydroxyvitamin D [25(OH)D] (n=120,618), 25-hydroxyvitamin D3 [25(OH)D3] (n=40,562), and C3-epimer-25-hydroxyvitamin D3 [C3-epi-25(OH)D3] (n=40,562) in Europeans were used, along with data on urticaria and its subtypes from FinnGen consortium (R10 release). For validation, we performed additional MR analyses using a larger dataset that meta-analyzed data from the UK Biobank and GWAS results from the SUNLIGHT consortium (n=496,946) as exposure variables. We performed compre-hensive sensitivity analyses, including heterogeneity tests, pleiotropy assessments, and leave-one-out analyses to evaluate result robustness. Statistical power calculations were conducted to validate the reliability of our findings.
resultsMR analysis revealed a causal protective effect of higher total 25(OH)D levels on urticaria risk [odds ratio (OR) = 0.81, 95% confidence interval (CI):0.69-0.95, p =0.008, statistical power = 81.1%]. Similar causal effects were observed for 25(OH)D3 levels (OR = 0.85, 95% CI: 0.74-0.98, p = 0.023, statistical power = 67.4%).These findings were validated in the replication cohort using serum 25(OH)D measurements (OR = 0.69, 95%CI: 0.56-0.85, p = 0.001, statistical power = 96.1%). Sensitivity analyses showed no significant heterogeneity or pleiotropy. Reverse MR analysis found no evidence that genetic risk of urticaria affects vitamin D levels, suggesting a potentially unidirectional causal relationship.
conclusionsThis study provides the first genetic evidence that higher vitamin D levels may reduce urticaria risk, offering a new theoretical basis for urticaria prevention and treatment strategies.
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